Konarska Monika, Wrona Anna Natalia, Aleksandrovych Veronika, Bereza Tomasz, Sajewicz Marek, Gach-Kuniewicz Barbara, Lis Maciej, Komnata Kinga, Paziewski Mateusz, Maleszka Aleksandra, Depukat Paweł, Solewski Bernard, Warchoł Łukasz
Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland.
Folia Med Cracov. 2016;56(2):37-43.
Uterine leiomyomata present major problem for females. Although they are benign tumors their frequency is associated with many symptoms like infertility, abdominal pain, menorrhagia. Authors based on their own morphological studies and review of the literature try to indicate main factors causing angiogenesis within leiomyomata and its influence on tumor growth. The strongest proangiogenic factor seems to be hypoxia, which stimulates up- and down-regulation of numerous genetically determined substances. Also mechanical pressure acting upon newly growing vessels is one of the factors which may determine formation of so called "vascular pseudocapsule" around the lesion.
子宫平滑肌瘤给女性带来了重大问题。尽管它们是良性肿瘤，但其高发率与许多症状相关，如不孕、腹痛、月经过多。作者基于自身的形态学研究及文献综述，试图指出导致平滑肌瘤内血管生成的主要因素及其对肿瘤生长的影响。最强的促血管生成因子似乎是缺氧，它刺激多种基因决定物质的上调和下调。此外，作用于新生长血管的机械压力也是可能决定病变周围所谓“血管假包膜”形成的因素之一。
