Przybylska-Feluś Magdalena, Furgała Agata, Kaszuba-Zwoińska Jolanta, Thor Piotr, Mach Tomasz, Zwolińska-Wcisło Małgorzata
Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland.
Department of Gastroenterology and Hepatology; Department of Clinical Dietetics, Jagiellonian University Medical College, Kraków, Poland.
Folia Med Cracov. 2016;56(2):56-72.
BACKGROUND/AIMS: The aim of the study was to analyze the effect of celiac disease(CED) on the upper-gut motility and release of enteral hormones (ghrelin and pancreatic peptide (PP)).
the study included 25 patients diagnosed with CED and 30 healthy controls. Gastric myoelectric activities (EGG) in a fasted and fed state were recorded. The plasma concentrations of ghrelin and PP were determined. R e s u l t s: CED patients presented in a fasted state a decreased percentage of normogastria 54.8 ± 24.5 vs. 86 ± 12.3%, p = 0.02 and slow wave coupling (SWC) 52.7 ± 13.4 vs. 77.4 ± 11.9%; p = 0.00001 with increased dominant power (DP) 11.6 ± 1.5 vs. 11.1 ± 1.1. Contrary to the controls, they did not show an improvement in the percentage of normogastria, DP and SWC when examined in a fed state (p 〈0.05). Furthermore, CED patients presented with significantly lower fasting plasma concentrations of ghrelin 156.8 ± 86.7 vs. 260.2 ± 87.6 pg/ml, p = 0.0002 and significantly higher fasting PP levels than did the controls 265.2 ± 306.3 vs. 54.1 ± 54.6 pg/ml, p = 0.0005. C o n c l u s i o n: CED affects gastric myoelectric activity (decreasing normogastria and coupling) and causes changes in fasting concentrations of enteral hormones (decrease in ghrelin and an increase in PP). Gastric myoelectric response to food is abolished in CED patients, probably due to the neurohormonal changes induced by primary inflammation associated with this disease.
背景/目的：本研究旨在分析乳糜泻（CED）对上消化道动力及肠内激素（胃饥饿素和胰多肽（PP））释放的影响。
本研究纳入25例确诊为CED的患者和30例健康对照者。记录空腹和进食状态下的胃肌电活动（EGG）。测定胃饥饿素和PP的血浆浓度。结果：CED患者在空腹状态下正常胃电活动百分比降低（54.8±24.5%对86±12.3%，p = 0.02），慢波耦合（SWC）降低（52.7±13.4对77.4±11.9%；p = 0.00001），而优势功率（DP）增加（11.6±1.5对11.1±1.1）。与对照组相反，他们在进食状态下检查时，正常胃电活动百分比、DP和SWC未显示改善（p＜0.05）。此外，CED患者空腹血浆胃饥饿素浓度显著降低（156.8±86.7对260.2±87.6 pg/ml，p = 0.0002），空腹PP水平显著高于对照组（265.2±306.3对54.1±54.6 pg/ml，p = 0.0005）。结论：CED影响胃肌电活动（降低正常胃电活动和耦合），并导致肠内激素空腹浓度发生变化（胃饥饿素降低，PP增加）。CED患者对食物的胃肌电反应消失，可能是由于与该疾病相关的原发性炎症引起的神经激素变化所致。
