Pieramico O, Malfertheiner P, Nelson D K, Glasbrenner B, Ditschuneit H
Department of Internal Medicine and Gastroenterology, University of Ulm, FR Germany.
Int J Obes. 1990 Dec;14(12):1005-11.
Changes in pancreatic polypeptide plasma concentrations have been reported in obesity. It has been suggested that altered PP plasma levels may play a role in the abnormal food intake observed in obesity. Earlier studies, however, have not considered the physiological fluctuations of PP during fasting. We examined PP plasma concentrations in 12 subjects with severe obesity and in 10 normal subjects during the entire cycle of interdigestive motility and after the administration of a standard mixed meal. Obese patients and healthy controls showed similar fluctuations of PP during individual phases of the migrating motor complex (MMC) and reached their peak PP plasma levels (134 +/- 35 (s.e.m.) pg/ml in controls vs 113 +/- 17 pg/ml in obese subjects) during phase III activity. Following the test meal, prompt release of PP occurred which was significantly higher than basal values at each 15 min interval during the first postprandial hour in both controls and obese patients. The integrated PP postprandial response at 60 min did not differ between obese patients (163 +/- 15 pg/ml.h) and controls (198 +/- 37 pg/ml.h; n.s.). A putative causal role for PP in obesity thus seems very unlikely.
肥胖患者的血浆胰多肽浓度已有变化的报道。有人提出，血浆胰多肽水平的改变可能在肥胖患者异常的食物摄入中起作用。然而，早期研究并未考虑禁食期间胰多肽的生理波动。我们检测了12名严重肥胖受试者和10名正常受试者在消化间期运动的整个周期以及给予标准混合餐后的血浆胰多肽浓度。肥胖患者和健康对照在移行性运动复合波（MMC）各阶段的胰多肽波动相似，且在Ⅲ期活动时达到血浆胰多肽峰值水平（对照组为134±35（标准误）pg/ml，肥胖受试者为113±17 pg/ml）。进食试验餐之后，胰多肽迅速释放，在餐后第一小时内，每15分钟时的胰多肽水平均显著高于基础值，在对照组和肥胖患者中均如此。肥胖患者60分钟时餐后胰多肽的综合反应（163±15 pg/ml·小时）与对照组（198±37 pg/ml·小时；无显著性差异）并无不同。因此，胰多肽在肥胖中可能的因果作用似乎非常小。
