Cook Matthew David, Myers Stephen David, Gault Mandy Lucinda, Edwards Victoria Charlotte, Willems Mark Elisabeth Theodorus
Department of Sport and Exercise Sciences, University of Chichester, College Lane, Chichester, PO19 6PE, UK.
Eur J Appl Physiol. 2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24.
Blackcurrant contains anthocyanins that could alter cardiovascular function and reduce cardiovascular disease risk. We examined dose responses of New Zealand blackcurrant (NZBC) extract on cardiovascular function during supine rest.
Fifteen endurance-trained male cyclists (age: 38 ± 12 years, height: 178 ± 5 cm, body mass: 76 ± 10 kg, [Formula: see text]: 56 ± 8 mL kg min, mean ± SD) were randomly assigned using a counterbalanced Latin square design to complete four conditions, a control of no NZBC, or one of three doses (300, 600 or 900 mg day) of NZBC extract (CurraNZ™) for 7-days with a 14-day washout. Cardiovascular function (i.e., blood pressure, heart rate, ejection time, cardiac output, stroke volume, and total peripheral resistance) during supine rest was examined (Portapres Model 2).
Systolic and diastolic blood pressure, heart rate and ejection time were unchanged by NZBC. A dose effect (P < 0.05) was observed for cardiac output, stroke volume, and total peripheral resistance. A trend for a dose effect was observed for mean arterial blood pressure. Cardiac output increased by 0.6 ± 0.6 L min (15%) and 1.0 ± 1.0 L min (28%) and stroke volume by 5 ± 8 mL (7%) and 6 ± 17 mL (18%) between control and 600, and 900 mg day, respectively. Total peripheral resistance decreased by 4 ± 3 mmHg L min (20%) and 5 ± 9 mmHg L min (20%) for 600, and 900 mg day.
Seven-days intake of New Zealand blackcurrant extract demonstrated dose-dependent changes on some cardiovascular parameters during supine rest in endurance-trained male cyclists.
黑加仑含有花青素，可能会改变心血管功能并降低心血管疾病风险。我们研究了新西兰黑加仑（NZBC）提取物在仰卧休息期间对心血管功能的剂量反应。
15名耐力训练的男性自行车运动员（年龄：38±12岁，身高：178±5厘米，体重：76±10千克，[公式：见正文]：56±8毫升·千克·分钟，平均值±标准差）采用平衡拉丁方设计随机分配，以完成四种情况，即不服用NZBC的对照，或三种剂量（300、600或900毫克/天）的NZBC提取物（CurraNZ™）之一，为期7天，洗脱期为14天。检查仰卧休息期间的心血管功能（即血压、心率、射血时间、心输出量、每搏输出量和总外周阻力）（Portapres Model 2）。
NZBC对收缩压、舒张压、心率和射血时间无影响。在心输出量、每搏输出量和总外周阻力方面观察到剂量效应（P<0.05）。在平均动脉血压方面观察到剂量效应趋势。与对照组相比，600毫克/天和900毫克/天组的心输出量分别增加了0.6±0.6升/分钟（15%）和1.0±1.0升/分钟（28%），每搏输出量分别增加了5±8毫升（7%）和6±17毫升（18%）。600毫克/天和900毫克/天组的总外周阻力分别降低了4±3毫米汞柱·升/分钟（20%）和5±9毫米汞柱·升/分钟（20%）。
在耐力训练的男性自行车运动员仰卧休息期间，摄入7天的新西兰黑加仑提取物对一些心血管参数表现出剂量依赖性变化。
