Yang Shaoping, Yang Rong, Liang Shengwen, Wang Jing, Weaver Nancy L, Hu Ke, Hu Ronghua, Trevathan Edwin, Huang Zhen, Zhang Yiming, Yin Ting, Chang Jen Jen, Zhao Jinzhu, Shen Longjiao, Dong Guanghui, Zheng Tongzhang, Xu Shunqing, Qian Zhengmin, Zhang Bin
Wuhan Medical and Health Center for Women and Children, 100 Hongkong Road, Wuhan, Hubei, 430015, China.
Wuhan Environmental Monitoring Center, 422 Xinhua Road, Wuhan, Hubei, China, 430015.
Arch Womens Ment Health. 2017 Apr;20(2):283-290. doi: 10.1007/s00737-016-0697-2. Epub 2016 Dec 24.
This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17-1.70; adjusted OR 1.29, 95% CI 1.07-1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.
本研究是一项嵌套病例对照研究，源自于在中国武汉开展的一项基于人群的队列研究。目的是评估孕期抑郁症状（DDP）、孕期焦虑（ADP）以及孕期抑郁伴焦虑（DADP）与低出生体重（LBW）之间的关联，并检验早产（PTB）对这些关联的影响程度。采用逻辑回归分析对DDP、ADP和DADP与LBW之间的关联进行建模。模型按是否存在PTB进行分层，以检验调节效应。在队列研究中，2853例有低出生体重儿（病例组）；5457名孕妇作为对照组。仅患有DDP或ADP的女性生育低出生体重儿的风险并未增加，但DADP与低出生体重风险增加相关（粗比值比1.41，95%置信区间1.17 - 1.70；校正比值比1.29，95%置信区间1.07 - 1.57），并且DADP与LBW之间的显著关联在早产中尤为明显，而在足月产中则不明显。我们的数据表明，DADP与低出生体重风险增加有关，并且这种关联在早产中最为显著。
