Yoshida K, Hattori T, Abe H, Akimoto M
Department of Urology, Nippon Medical School.
Hinyokika Kiyo. 1989 May;35(5):885-9.
A 66-year-old female complained of fever and lumbar pain was diagnosed as the squamous cell carcinoma associated with vesical leukoplakia cystoscopically. Histopathological figures showed various forms of squamous metaplasia, involving squamous cell carcinoma nests within it. Now, the relationship between vesical leukoplakia and squamous cell carcinoma is not obscure. Then the treatment of the leukoplakia has been considered conservatively (fulguration, acidification of the urine and anti-microbials). Now, we can classify the lesions of squamous metaplasias into two types in the urinary bladder. The possibility of the malignant change in the leukoplakia lesions could be suggestive of the histological characteristics; irregularly down growth and disarrangement of the basal cells and/or dispersed basement membrane in rete pegs in the metaplasia.
一名66岁女性因发热和腰痛就诊，经膀胱镜检查诊断为与膀胱白斑相关的鳞状细胞癌。组织病理学图像显示各种形式的鳞状化生，其中包含鳞状细胞癌巢。目前，膀胱白斑与鳞状细胞癌之间的关系并不模糊。随后，对白斑的治疗采取了保守方法（电灼、尿液酸化和使用抗菌药物）。现在，我们可以将膀胱鳞状化生病变分为两种类型。白斑病变发生恶性变化的可能性可能提示组织学特征，即化生中基底细胞不规则向下生长、排列紊乱和/或 rete 钉突中基底膜分散。
