Iritani Y, Maekawa M, Sugimura K, Hanada M, Nakanishi J
Hinyokika Kiyo. 1984 Jun;30(6):803-8.
A patient who had vesical leukoplakia with unusual macroscopic and histological findings was studied. The mucous membrane of the urinary bladder in this patient showed a tumor-like proliferation similar to verrucous hyperplasia which is often found in the oral mucosa. We propose a new classification of vesical leukoplakia, dividing it into three groups, atrophic, hypertrophic and verrucous types. The atrophic type has a heavily keratinized, flat and thin type of epithelium with features resembling lichen sclerosis et atrophius. Histologically, it shows a variable degree of hyperkeratosis but no parakeratosis. The hypertrophic type has histological characteristics resembling features of leukoplakia in sites elsewhere in the body, which is marked by hyperkeratosis and irregular hyperplasia of the prickle cell layer with lengthening and abnormality in shape of rete pegs. The verrucous type has very rare features of coral shape, white color and verrucous proliferation. Histologically, this type shows severe hyperkeratosis, parakeratosis and elongation of the rete pegs, but no irregular invasion can be observed.
对一名患有膀胱白斑且有异常大体和组织学表现的患者进行了研究。该患者膀胱黏膜呈现出类似疣状增生的肿瘤样增殖，这种情况在口腔黏膜中较为常见。我们提出了一种膀胱白斑的新分类方法，将其分为三组，即萎缩型、肥厚型和疣状型。萎缩型具有高度角化、扁平且薄的上皮类型，其特征类似于硬化性萎缩性苔藓。组织学上，它表现出不同程度的角化过度，但无不全角化。肥厚型具有类似于身体其他部位白斑的组织学特征，其特点为角化过度和棘细胞层不规则增生，伴有 rete 钉突延长和形态异常。疣状型具有非常罕见的珊瑚状、白色和疣状增殖特征。组织学上，该类型表现为严重角化过度、不全角化和 rete 钉突延长，但未观察到不规则浸润。
