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蛋白质和肽类生物制药:概述

Protein and Peptide Biopharmaceuticals: An Overview.

作者信息

Agyei Dominic, Ahmed Ishtiaq, Akram Zain, Iqbal Hafiz M N, Danquah Michael K

机构信息

Department of Chemical Engineering, Curtin University, Malaysia.

出版信息

Protein Pept Lett. 2017;24(2):94-101. doi: 10.2174/0929866523666161222150444.

Abstract

Bioactive proteins and peptides are recognised as novel therapeutic molecules with varying biological properties for potential medical applications. Development of protein and peptidebased therapeutic products for human use is growing steadily as they continue to receive an increasing rate of approval by the United States Food and Drugs Administration (US FDA). In this short review, we describe the current status and methodologies involved in the synthesis of protein and peptide biopharmaceuticals with an emphasis on the drivers and restrains to their exploitation in the therapeutic products sector.

摘要

生物活性蛋白和肽被认为是具有多种生物学特性的新型治疗分子,具有潜在的医学应用价值。随着基于蛋白质和肽的治疗产品不断获得美国食品药品监督管理局(US FDA)越来越高的批准率,用于人类的此类治疗产品的开发正在稳步增长。在这篇简短的综述中,我们描述了蛋白质和肽生物制药合成的现状和方法,重点关注其在治疗产品领域开发的驱动因素和限制因素。

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