Yalincetin Berna, Bora Emre, Binbay Tolga, Ulas Halis, Akdede Berna Binnur, Alptekin Koksal
Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Department of Psychiatry, Dokuz Eylül University Medical School, Izmir 35340, Turkey.
Schizophr Res. 2017 Jul;185:2-8. doi: 10.1016/j.schres.2016.12.015. Epub 2016 Dec 22.
Historically, formal thought disorder has been considered as one of the distinctive symptoms of schizophrenia. However, research in last few decades suggested that there is a considerable clinical and neurobiological overlap between schizophrenia and bipolar disorder (BP). We conducted a meta-analysis of studies comparing positive (PTD) and negative formal thought disorder (NTD) in schizophrenia and BP. We included 19 studies comparing 715 schizophrenia and 474 BP patients. In the acute inpatient samples, there was no significant difference in the severity of PTD (d=-0.07, CI=-0.22-0.09) between schizophrenia and BP. In stable patients, schizophrenia was associated with increased PTD compared to BP (d=1.02, CI=0.35-1.70). NTD was significantly more severe (d=0.80, CI=0.52-0.1.08) in schizophrenia compared to BP. Our findings suggest that PTD is a shared feature of both schizophrenia and BP but persistent PTD or NTD can distinguish subgroups of schizophrenia from BP and schizophrenia patients with better clinical outcomes.
从历史上看，形式思维障碍一直被视为精神分裂症的典型症状之一。然而，过去几十年的研究表明，精神分裂症和双相情感障碍（BP）在临床和神经生物学方面存在相当大的重叠。我们对比较精神分裂症和双相情感障碍中阳性（PTD）和阴性形式思维障碍（NTD）的研究进行了荟萃分析。我们纳入了19项研究，比较了715名精神分裂症患者和474名双相情感障碍患者。在急性住院样本中，精神分裂症和双相情感障碍之间的PTD严重程度没有显著差异（d=-0.07，CI=-0.22-0.09）。在病情稳定的患者中，与双相情感障碍相比，精神分裂症与PTD增加相关（d=1.02，CI=0.35-1.70）。与双相情感障碍相比，精神分裂症中的NTD明显更严重（d=0.80，CI=0.52-1.08）。我们的研究结果表明，PTD是精神分裂症和双相情感障碍的共同特征，但持续性PTD或NTD可以区分精神分裂症亚组与双相情感障碍以及临床结局较好的精神分裂症患者。
