Zhu Ziyan, Ye Luyi, Li Qin, Gao Hongwei, Tan Yinxia, Cai Wei
Shanghai Blood Center, Shanghai, China.
Shanghai Blood Center, Shanghai, China.
Transfus Med Rev. 2017 Apr;31(2):102-106. doi: 10.1016/j.tmrv.2016.11.004. Epub 2016 Nov 24.
ABO subtypes and RhD variants are the most studied blood groups in China. Some of the polymorphisms in these two blood groups have direct clinical relevance. Molecular diagnosis of blood group polymorphisms is underway in China. In addition, research groups have developed methods such as screening for blood group mimetic peptides using phage display technology. New reagents, akin to antibodies directed against RhD and ABO, are being investigated using aptamer-based techniques. Progress is also being made in the development of synthetic exoglycosidases for conversion of group A and/or B antigens to group O. Development of methoxy-polyethylene-glycol modified red cells has been successful in vitro but has not reached clinical application. In this paper, we summarize red cell immunohematology research that has been conducted in China.
ABO亚型和RhD变异体是中国研究最多的血型。这两种血型中的一些多态性具有直接的临床相关性。中国正在开展血型多态性的分子诊断。此外，研究团队已经开发出了一些方法，比如利用噬菌体展示技术筛选血型模拟肽。正在使用基于适配体的技术研究类似于抗RhD和ABO抗体的新型试剂。在开发用于将A和/或B抗原转化为O型的合成外切糖苷酶方面也取得了进展。甲氧基聚乙二醇修饰红细胞的开发在体外已取得成功，但尚未应用于临床。在本文中，我们总结了中国开展的红细胞免疫血液学研究。
