Xiao Fenglai, An Dongmei, Zhou Dong
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Seizure. 2017 Jan;44:37-41. doi: 10.1016/j.seizure.2016.10.003. Epub 2016 Oct 14.
Epilepsy has been recognized as a brain network disorder. Therefore, functional MRI (fMRI)-based connectivity is an ideal technique for exploring the complex effects of epilepsy on the brain. Functional connectivity studies have provided insights into the physiopathogenesis of the epileptic network underlying focal epilepsies, genetic generalized epilepsy, and specific epileptic syndromes. An increasing number of studies have focused on the deleterious effects of epilepsy on other brain networks to help to explain cognitive deficits and psychiatric symptoms. Anti-epileptic treatment studies have yielded information about the side effects and the restoration of functional abnormalities after using the drug. Researchers who have examined predictors of surgical outcomes have suggested that there might be identifiable pre-surgical patterns of functional connectivity that are associated with a greater likelihood of positive cognitive or seizure outcomes. However, knowledge regarding the role of fMRI connectivity remains limited in clinical settings. Further validation through invasive investigations and follow-up studies is required for its reliable application in the clinical management of individual patients.
癫痫已被公认为一种脑网络疾病。因此，基于功能磁共振成像（fMRI）的连通性是探索癫痫对大脑复杂影响的理想技术。功能连通性研究为局灶性癫痫、遗传性全身性癫痫和特定癫痫综合征背后的癫痫网络的生理病理机制提供了见解。越来越多的研究关注癫痫对其他脑网络的有害影响，以帮助解释认知缺陷和精神症状。抗癫痫治疗研究已经得出了关于药物副作用以及使用药物后功能异常恢复情况的信息。研究手术结果预测因素的研究人员表明，可能存在可识别的术前功能连通性模式，这些模式与更好的认知或癫痫发作结果的可能性相关。然而，在临床环境中，关于fMRI连通性作用的知识仍然有限。需要通过侵入性研究和随访研究进行进一步验证，以便其在个体患者的临床管理中可靠应用。
