Department of Environmental Health Sciences, School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Department of Environmental Health Sciences, School of Public Health, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea; Center for Human and Environmental Microbiome, Institute of Health and Environment, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea.
Cell Host Microbe. 2017 Jan 11;21(1):97-105. doi: 10.1016/j.chom.2016.11.010. Epub 2016 Dec 22.
While the vaginal ecosystem is maintained through mutualistic relationships between the host and the vaginal bacteria, the effect of host genetics on the vaginal microbiota has not been well characterized. We examined the heritability of vaginal microbiota and its association with obesity in 542 Korean females, including 222 monozygotic and 56 dizygotic twins. The vaginal microbiota significantly varied depending on host menopausal status and bacterial vaginosis. Lactobacillus and Prevotella, whose relative abundances are strongly associated with bacterial vaginosis, were the most heritable bacteria among the beneficial and potentially pathogenic vaginal microbiota, respectively. Candidate gene analysis revealed an association between genetic variants of interleukin-5 and the abundance of Prevotella sp. Furthermore, host obesity significantly increased the diversity of the vaginal microbiota in association with Prevotella. Our results provide insight into the effect of host genetics on the vaginal microbiota and their association with both vaginal and non-vaginal health.
虽然阴道生态系统通过宿主和阴道细菌之间的互利关系得以维持，但宿主遗传因素对阴道微生物群的影响尚未得到很好的描述。我们在 542 名韩国女性中研究了阴道微生物群的遗传性及其与肥胖的关系，其中包括 222 对同卵双胞胎和 56 对异卵双胞胎。阴道微生物群受宿主绝经状态和细菌性阴道病的影响显著变化。乳酸杆菌和普雷沃氏菌的相对丰度与细菌性阴道病密切相关，分别是有益和潜在致病阴道微生物群中最具遗传性的细菌。候选基因分析显示，白细胞介素 5 的遗传变异与普雷沃氏菌属的丰度之间存在关联。此外，宿主肥胖显著增加了阴道微生物群的多样性，并与普雷沃氏菌属有关。我们的研究结果提供了对宿主遗传因素对阴道微生物群及其与阴道和非阴道健康关系的影响的深入了解。
