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本文引用的文献

1
Surgical treatment for pelvic giant cell tumor: a multi-center study.骨盆骨巨细胞瘤的外科治疗:一项多中心研究
World J Surg Oncol. 2016 Apr 5;14:104. doi: 10.1186/s12957-016-0862-0.
2
The use of iliac stem prosthesis for acetabular defects following resections for periacetabular tumors.髂骨柄假体在髋臼周围肿瘤切除术后髋臼缺损中的应用。
ScientificWorldJournal. 2013 Oct 22;2013:717031. doi: 10.1155/2013/717031. eCollection 2013.
3
Treatment and outcome of giant cell tumors of the pelvis.骨盆骨巨细胞瘤的治疗与预后
Acta Orthop. 2009 Oct;80(5):590-6. doi: 10.3109/17453670903350123.
4
Pelvic reconstruction using saddle prosthesis following limb salvage operation for periacetabular tumour.髋臼周围肿瘤保肢手术后使用鞍形假体进行骨盆重建。
J Orthop Surg (Hong Kong). 2006 Aug;14(2):155-62. doi: 10.1177/230949900601400210.
5
Functional results after partial pelvic resection in Ewing's sarcoma of the ilium.髂骨尤因肉瘤行部分骨盆切除术后的功能结果。
Arch Orthop Trauma Surg. 1999;119(3-4):199-204. doi: 10.1007/s004020050390.
6
Surgical management of innominate giant cell tumor.无名巨细胞瘤的外科治疗
Clin Orthop Relat Res. 1996 Aug(329):281-7. doi: 10.1097/00003086-199608000-00035.
7
Giant cell tumor of the ischium. A report of two cases and review of the literature.坐骨巨细胞瘤。两例报告并文献复习。
Skeletal Radiol. 1988;17(1):46-51. doi: 10.1007/BF00361455.

定制髂骨假体用于巨细胞瘤重建:一种独特的治疗方法。

Customized iliac prosthesis for reconstruction in giant cell tumour: A unique treatment approach.

作者信息

Verma Tarun, Sharma Ankur, Sharma Amit, Maini Lalit

机构信息

Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.

出版信息

J Clin Orthop Trauma. 2016 Oct-Dec;7(Suppl 1):35-40. doi: 10.1016/j.jcot.2016.10.001. Epub 2016 Oct 21.

DOI:10.1016/j.jcot.2016.10.001
PMID:28018068
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167515/
Abstract

Giant cell tumour (GCT) of flat bones of pelvis is extremely rare. GCT of the ilium and ischium represent less than 0.05% of all GCT. Iliac bone GCT has been treated traditionally by intra-lesion curettage with bone grafting, wide resection with or without reconstruction and hemi-pelvectomy in very aggressive tumours. None of the above treatments were without morbidities. Reconstruction using bone grafts and bone cement has also been inadequate. In GCT, where life expectancy is not decreased significantly, surgical treatment should be aimed at giving optimum functional outcome. We are reporting here a rare case of giant cell tumour of ilium bone in a 25-year-old female and its unique treatment approach. We designed a computed tomography (CT) based customized iliac prosthesis using Materialise Mimics and 3-Matic software. 3D model of pelvis was generated from the CT. After deciding the extent of resection on affected side, we virtually mirrored an identical portion of opposite ilium to the affected side. Connecting plates were made over the mirrored part and merged with it. Multiple relevant holes were made to attach various muscles to the prosthesis. Prosthesis was made in medical grade titanium by using Computerized Numerical Control (CNC) machine. The method is called as computer based subtractive manufacturing. Wide resection was done and the prosthesis was placed using multiple 3.5 millimetres screws through the connecting plates. Muscles were stitched to relevant holes using ethibond suture. Post-operative course was unremarkable. Patient was made to walk with full weight bearing after 5 weeks. Powers of abductors at 6 months is 4/5 and patient walks normally without a limp.

摘要

骨盆扁平骨的骨巨细胞瘤极为罕见。髂骨和坐骨的骨巨细胞瘤占所有骨巨细胞瘤的比例不到0.05%。传统上,髂骨骨巨细胞瘤的治疗方法包括病灶内刮除植骨、广泛切除(可重建或不重建)以及对侵袭性很强的肿瘤进行半骨盆切除术。上述治疗方法均存在一定的并发症。使用骨移植和骨水泥进行重建也并不理想。在骨巨细胞瘤患者中,其预期寿命并未显著缩短,手术治疗应旨在实现最佳的功能预后。在此,我们报告一例25岁女性髂骨骨巨细胞瘤的罕见病例及其独特的治疗方法。我们使用Materialise Mimics和3-Matic软件设计了一种基于计算机断层扫描(CT)的定制髂骨假体。从CT生成骨盆的三维模型。在确定患侧的切除范围后,我们将对侧髂骨的相同部分虚拟镜像到患侧。在镜像部分制作连接板并与之合并。制作多个相关的孔以便将各种肌肉附着到假体上。使用计算机数控(CNC)机器用医用级钛制作假体。这种方法称为基于计算机的减法制造。进行广泛切除,通过连接板使用多个3.5毫米螺钉放置假体。使用Ethibond缝线将肌肉缝合到相关的孔上。术后过程顺利。5周后患者开始完全负重行走。6个月时外展肌力量为4/5,患者行走正常,无跛行。