Daya S
Department of Obstetrics and Gynecology, McMaster University.
Am J Obstet Gynecol. 1989 Oct;161(4):1009-11. doi: 10.1016/0002-9378(89)90773-4.
Inadequate production of progesterone by the corpus luteum results in luteal phase deficiency, which is a frequent cause of recurrent spontaneous abortion. The diagnosis is made by assessment of endometrial biopsy specimens. Measurement of serum progesterone offers a less invasive alternative, but its utility as a diagnostic test is limited since there is no agreement on the level that will accurately differentiate between normal and luteal phase deficiency cycles. The purpose of this study was to determine whether there was an optimal time in the menstrual cycle when serum progesterone measurement could improve the diagnostic accuracy of the test. The results demonstrate that this time period is day 25 to day 26 and not the midluteal phase as has previously been suggested. The discriminatory level was found to be 21 nmol/L and provided a test with sensitivity of 81% and specificity of 73%.
黄体分泌孕酮不足会导致黄体期缺陷，这是复发性自然流产的常见原因。诊断通过评估子宫内膜活检标本进行。血清孕酮检测提供了一种侵入性较小的替代方法，但其作为诊断测试的效用有限，因为对于能准确区分正常周期和黄体期缺陷周期的水平尚无共识。本研究的目的是确定月经周期中血清孕酮检测能提高诊断准确性的最佳时间。结果表明，这个时间段是第25天至第26天，而非先前认为的黄体中期。发现鉴别水平为21 nmol/L，该检测的灵敏度为81%，特异性为73%。
