Babalioğlu R, Varol F G, Ilhan R, Yalçin O, Cizmecioğlu F
Department of Gynaecology and Obstetrics, Vakif Gureba Hospital, Istanbul, Turkey.
J Assist Reprod Genet. 1996 Apr;13(4):306-9. doi: 10.1007/BF02070143.
Histologically documented luteal-phase defects (LPD) have been detected in 20-40% of women with recurrent spontaneous abortions. In 28 patients with recurrent spontaneous abortions, luteal-phase serum progesterone (P) levels (days 19, 21, 23, 25) and endometrial biopsies were evaluated.
On the basis of endometrial biopsy findings, the patients were separated into two groups: Group 1, recurrent spontaneous abortions with LPDs (n = 18); and Group 2, recurrent spontaneous abortions with normal biopsies (n = 7). The data are shown in the table below.
This study demonstrated that the P values found in Group 1 were significantly lower than those in Group 2, almost throughout the luteal phase. The results also indicate a close relationship between the P profile in the luteal phase and endometrial biopsy.
在20%至40%的复发性自然流产女性中检测到组织学记录的黄体期缺陷（LPD）。对28例复发性自然流产患者的黄体期血清孕酮（P）水平（第19、21、23、25天）和子宫内膜活检进行了评估。
根据子宫内膜活检结果，将患者分为两组：第1组，有黄体期缺陷的复发性自然流产患者（n = 18）；第2组，活检正常的复发性自然流产患者（n = 7）。数据如下表所示。
本研究表明，几乎在整个黄体期，第1组的P值显著低于第2组。结果还表明黄体期的P曲线与子宫内膜活检之间存在密切关系。
