Eddie L W, Sutton B, Fitzgerald S, Bell R J, Johnston P D, Tregear G W
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Am J Obstet Gynecol. 1989 Oct;161(4):970-3. doi: 10.1016/0002-9378(89)90764-3.
In a study to determine if relaxin could be measured in milk and if so to correlate concentrations in milk and serum, paired samples of milk and serum were collected from 12 women 3 days after term delivery (term group), from 16 women 3 days after preterm delivery (preterm group), and from some of these patients 6 weeks after delivery (eight term and six preterm). Relaxin was measured by specific human relaxin radioimmunoassay. Relaxin from milk and sera behaved similarly in the relaxin radioimmunoassay and reverse-phase high-performance liquid chromatography. Concentrations of relaxin in sera and milk collected 3 days after delivery did not differ significantly within the term or preterm groups. Neither were there differences in relaxin levels in sera and milk between the term and preterm groups. At 6 weeks postpartum, relaxin was not measured in any sera but was measured in milk from six of eight patients in the term group and five of six patients in the preterm group. Relaxin concentrations in milk were higher in the preterm group. The presence of relaxin in milk at 6 weeks postpartum suggests a nonluteal site of synthesis.
在一项旨在确定乳汁中是否可检测到松弛素以及若可检测到，乳汁和血清中松弛素浓度是否相关的研究中，从12名足月分娩后3天的女性（足月组）、16名早产分娩后3天的女性（早产组）以及其中部分患者产后6周（8名足月和6名早产）采集了乳汁和血清配对样本。通过特异性人松弛素放射免疫测定法检测松弛素。乳汁和血清中的松弛素在松弛素放射免疫测定和反相高效液相色谱中表现相似。足月组或早产组中，分娩后3天采集的血清和乳汁中松弛素浓度无显著差异。足月组和早产组的血清和乳汁中松弛素水平也无差异。产后6周时，所有血清中均未检测到松弛素，但足月组8名患者中的6名以及早产组6名患者中的5名乳汁中检测到了松弛素。早产组乳汁中松弛素浓度更高。产后6周乳汁中存在松弛素提示存在非黄体合成部位。
