Petersen L K, Skajaa K, Uldbjerg N
Department of Obstetrics and Gynecology, Aarhus Kommunehospital, Denmark.
Br J Obstet Gynaecol. 1992 Apr;99(4):292-5. doi: 10.1111/j.1471-0528.1992.tb13725.x.
To determine whether high serum relaxin concentrations in the 30th week of pregnancy were associated with preterm labour.
Case-control study.
Two antenatal clinics of the Department of Obstetrics and Gynecology University Hospital of Aarhus.
A cohort of 991 women (82% of 1203 eligible) in the 30th week of pregnancy attending one of the two antenatal clinics. The cases comprised 23 (2.4%) women without pre-eclampsia or small for gestational age babies, who were delivered spontaneously before 37 completed weeks gestation. The control group of 46 women was randomly selected from the rest of the cohort, all of them were delivered at term.
Blood samples were collected at 30 weeks gestation and stored for analysis.
Serum relaxin concentrations estimated by ELISA technique, length of gestation at delivery.
The mean serum relaxin concentrations in the 30th week of pregnancy was 455 (SD 169) pg/ml and 327 (SD 139) pg/ml in the cases and controls, respectively (P = 0.003, t test). In women with preterm delivery a negative correlation was found between relaxin concentration in the 30th week of pregnancy and the gestational age at parturition (r = -0.53, P = 0.02).
High relaxin concentrations may be associated with preterm delivery but the present results need confirmation in large scale studies.
确定妊娠第30周时血清松弛素浓度升高是否与早产相关。
病例对照研究。
奥胡斯大学医院妇产科的两家产前诊所。
在两家产前诊所之一就诊的991名妊娠第30周的妇女（占1203名符合条件者的82%）。病例组包括23名（2.4%）无先兆子痫或小于胎龄儿的妇女，她们在妊娠37周前自然分娩。对照组46名妇女从队列其余部分随机选取，均足月分娩。
在妊娠30周时采集血样并储存用于分析。
采用ELISA技术测定血清松弛素浓度、分娩时的孕周。
妊娠第30周时，病例组和对照组的血清松弛素平均浓度分别为455（标准差169）pg/ml和327（标准差139）pg/ml（P = 0.003，t检验）。在早产妇女中，妊娠第30周时的松弛素浓度与分娩时的孕周呈负相关（r = -0.53，P = 0.02）。
高松弛素浓度可能与早产相关，但目前的结果需要大规模研究加以证实。
