Bell R J, Eddie L W, Lester A R, Wood E C, Johnston P D, Niall H D
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Br J Obstet Gynaecol. 1988 Dec;95(12):1264-7. doi: 10.1111/j.1471-0528.1988.tb06816.x.
This study is the first report of antenatal levels of relaxin measured by homologous radioimmunoassay in peripheral serum from patients who subsequently had a preterm delivery. Serial blood samples were collected antenatally from a group of subjects known to be at increased risk of preterm labour because of a past history of shortened pregnancy. Serum relaxin was measured using an homologous radioimmunoassay based on a synthetic bioactive analogue of the native hormone. In women whose pregnancies ended preterm most measurements were within the range of values previously established in normal antenatal patients although some measurements early in pregnancy were above the normal range. These findings suggest that low serum levels of relaxin are not causatively related to the onset of labour before term.
本研究首次报告了通过同源放射免疫测定法检测随后发生早产的患者外周血清中产前松弛素水平。从一组因既往有妊娠缩短病史而被认为早产风险增加的受试者中，在产前采集系列血样。使用基于天然激素合成生物活性类似物的同源放射免疫测定法测量血清松弛素。在妊娠早产的女性中，大多数测量值在先前正常产前患者所确定的范围内，尽管妊娠早期的一些测量值高于正常范围。这些发现表明，血清松弛素水平低与早产发作无因果关系。
