Bloom J N, Herman D C, Elin R J, Sliva C A, Ruddel M E, Nussenblatt R B, Palestine A G
Laboratory of Immunology, National Eye Institute, Bethesda.
Am J Ophthalmol. 1989 Oct 15;108(4):375-9. doi: 10.1016/s0002-9394(14)73304-5.
The results of laboratory tests performed after fluorescein angiography may be erroneous because of interference by intravenous fluorescein. We investigated this potential interference in four adults at intervals of five minutes, three hours, six hours, and 12 hours after fluorescein injection. We used a panel of serum and urine chemistry tests on seven commonly used instruments. A significant change in the reported concentration of a serum or urine analyte was defined as a result beyond +/- 3 coefficients of variation of the preinjection baseline value for the test on a specific instrument. The determinations of creatinine, total protein, cortisol, digoxin, quinidine, and thyroxine in serum were affected by intravenous fluorescein. The urine tests were unaltered. The physician must be aware of the problem of interpreting clinical chemistry results after fluorescein angiography.
荧光素血管造影术后进行的实验室检查结果可能因静脉注射荧光素的干扰而出现错误。我们在4名成年人中，于荧光素注射后5分钟、3小时、6小时和12小时的间隔时间对这种潜在干扰进行了研究。我们在7台常用仪器上进行了一组血清和尿液化学检测。血清或尿液分析物报告浓度的显著变化定义为，在特定仪器上该检测的注射前基线值的±3变异系数范围之外的结果。血清中肌酐、总蛋白、皮质醇、地高辛、奎尼丁和甲状腺素的测定受到静脉注射荧光素的影响。尿液检测未受影响。医生必须意识到荧光素血管造影术后解读临床化学检查结果时存在的问题。
