• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

术后癫痫发作缓解与持续之间的差异：癫痫手术后自动检测到的局灶性慢波。

The delta between postoperative seizure freedom and persistence: Automatically detected focal slow waves after epilepsy surgery.

作者信息

Schönherr Margit, Stefan Hermann, Hamer Hajo M, Rössler Karl, Buchfelder Michael, Rampp Stefan

机构信息

Epilepsy Center, Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany.

Department of Neurosurgery, University Hospital Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany.

出版信息

Neuroimage Clin. 2016 Dec 5;13:256-263. doi: 10.1016/j.nicl.2016.12.001. eCollection 2017.

DOI:10.1016/j.nicl.2016.12.001
PMID:28018852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5167245/
Abstract

OBJECTIVE

In this study, we use a novel automated method for localization and quantitative comparison of magnetoencephalographic (MEG) delta activity in patients with and without recurrent seizures after epilepsy surgery as well as healthy controls.

METHODS

We identified the generators of delta activity by source location in frequency domain between 1 and 4 Hz in spontaneous MEG data. Comparison with healthy control subjects by z-transform emphasized relative changes of activation in patients. The individual results were compared to spike localizations and statistical group analysis was performed. Additionally, MEG results were compared to 1-4 Hz activity in invasive EEG (iEEG) in two patients, in whom this data was available.

RESULTS

Patients with recurrent seizures exhibited significantly increased focal MEG delta activity both in comparison to healthy controls and seizure free patients. This slow activity showed a correlation to interictal epileptic activity and was not explained by consequences of the resection alone. In two patients with iEEG, iEEG analysis was concordant with the MEG findings.

SIGNIFICANCE

The quantity of delta activity could be used as a diagnostic marker for recurrent seizures. The close relation to epileptic spike localizations and the resection volume of patients with successful second surgery imply involvement in seizure recurrence. This initial evidence suggests a potential application in the planning of second epilepsy surgery.

摘要

目的

在本研究中，我们使用一种新颖的自动化方法，对癫痫手术后有或无复发性癫痫发作的患者以及健康对照者的脑磁图（MEG）δ活动进行定位和定量比较。

方法

我们通过对自发MEG数据中1至4赫兹频域的源定位来确定δ活动的产生源。通过z变换与健康对照受试者进行比较，强调患者激活的相对变化。将个体结果与棘波定位进行比较，并进行统计组分析。此外，在两名有创脑电图（iEEG）数据可用的患者中，将MEG结果与iEEG中的1至4赫兹活动进行比较。

结果

与健康对照者和无癫痫发作的患者相比，复发性癫痫发作的患者表现出明显增加的局灶性MEGδ活动。这种慢活动与发作间期癫痫活动相关，并非仅由切除的后果所解释。在两名有iEEG的患者中，iEEG分析与MEG结果一致。

意义

δ活动的量可作为复发性癫痫发作的诊断标志物。与癫痫棘波定位和二次手术成功患者的切除体积密切相关，意味着其与癫痫复发有关。这一初步证据表明其在二次癫痫手术规划中具有潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/851809e07d9b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/6a7b73d2e13f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/34990176e182/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/851809e07d9b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/6a7b73d2e13f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/34990176e182/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f88/5167245/851809e07d9b/gr3.jpg

相似文献

1
The delta between postoperative seizure freedom and persistence: Automatically detected focal slow waves after epilepsy surgery.术后癫痫发作缓解与持续之间的差异：癫痫手术后自动检测到的局灶性慢波。
Neuroimage Clin. 2016 Dec 5;13:256-263. doi: 10.1016/j.nicl.2016.12.001. eCollection 2017.
2
Magnetoencephalography-guided surgery in frontal lobe epilepsy using neuronavigation and intraoperative MR imaging.使用神经导航和术中磁共振成像的额叶癫痫脑磁图引导手术
Epilepsy Res. 2016 Oct;126:26-36. doi: 10.1016/j.eplepsyres.2016.06.002. Epub 2016 Jun 25.
3
Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery.使用脑磁图进行致痫区定位可预测癫痫手术中的无癫痫发作情况。
Epilepsia. 2015 Jun;56(6):949-58. doi: 10.1111/epi.13002. Epub 2015 Apr 29.
4
Accuracy of MEG in localizing irritative zone and seizure onset zone: Quantitative comparison between MEG and intracranial EEG.脑磁图在定位激惹区和癫痫发作起始区的准确性：脑磁图与颅内脑电图的定量比较
Epilepsy Res. 2016 Nov;127:291-301. doi: 10.1016/j.eplepsyres.2016.08.013. Epub 2016 Aug 16.
5
Dynamic analysis on simultaneous iEEG-MEG data via hidden Markov model.基于隐马尔可夫模型的脑电-脑磁同步数据动态分析。
Neuroimage. 2021 Jun;233:117923. doi: 10.1016/j.neuroimage.2021.117923. Epub 2021 Mar 1.
6
The sensitivity and significance of lateralized interictal slow activity on magnetoencephalography in focal epilepsy.脑磁图中局灶性癫痫发作间期侧化慢波活动的敏感性及意义
Epilepsy Res. 2016 Mar;121:21-8. doi: 10.1016/j.eplepsyres.2016.01.009. Epub 2016 Jan 29.
7
Comparison of Brain Networks During Interictal Oscillations and Spikes on Magnetoencephalography and Intracerebral EEG.脑磁图和脑内脑电图发作间期振荡与尖峰期间脑网络的比较
Brain Topogr. 2016 Sep;29(5):752-65. doi: 10.1007/s10548-016-0501-7. Epub 2016 Jun 22.
8
Frequency domain beamforming of magnetoencephalographic beta band activity in epilepsy patients with focal cortical dysplasia.局灶性皮质发育不良癫痫患者脑磁图β频段活动的频域波束形成
Epilepsy Res. 2014 Sep;108(7):1195-203. doi: 10.1016/j.eplepsyres.2014.05.003. Epub 2014 May 13.
9
Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: a prospective long-term study.应用高密度脑电图和脑磁图进行癫痫手术的发作间期和发作期源定位：一项前瞻性长期研究。
Brain. 2019 Apr 1;142(4):932-951. doi: 10.1093/brain/awz015.
10
MEG correlates of epileptic high gamma oscillations in invasive EEG.MEG 与侵入性 EEG 中的癫痫性高 gamma 振荡的相关性。
Epilepsia. 2010 Aug;51(8):1638-42. doi: 10.1111/j.1528-1167.2010.02579.x.

引用本文的文献

1
Paroxysmal cortical slowing linked to drug-resistant epilepsy.与耐药性癫痫相关的阵发性皮质减慢
EBioMedicine. 2025 Jun;116:105780. doi: 10.1016/j.ebiom.2025.105780. Epub 2025 May 28.
2
Changes in cortical delta power during chronic invasive epilepsy monitoring.慢性侵入性癫痫监测期间皮质δ波功率的变化
Epilepsia. 2025 Aug;66(8):2995-3005. doi: 10.1111/epi.18419. Epub 2025 Apr 26.
3
MEG Node Degree for Focus Localization: Comparison with Invasive EEG.用于焦点定位的脑磁图节点度：与侵入性脑电图的比较

本文引用的文献

1
A guideline for head volume conductor modeling in EEG and MEG.脑电图和脑磁图头部容积导体建模指南。
Neuroimage. 2014 Oct 15;100:590-607. doi: 10.1016/j.neuroimage.2014.06.040. Epub 2014 Jun 25.
2
Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome.额叶癫痫中发作源位置的临床相关性及术后长期预后的预测
Seizure. 2014 Aug;23(7):553-9. doi: 10.1016/j.seizure.2014.04.006. Epub 2014 Apr 18.
3
Timing of early and late seizure recurrence after temporal lobe epilepsy surgery.
Biomedicines. 2023 Feb 2;11(2):438. doi: 10.3390/biomedicines11020438.
4
Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons.肿瘤周围神经元感觉反应衰减和癫痫易发性增强的分子变化。
Neuro Oncol. 2023 Aug 3;25(8):1463-1473. doi: 10.1093/neuonc/noad035.
5
Epileptic Seizure Detection Using Geometric Features Extracted from SODP Shape of EEG Signals and AsyLnCPSO-GA.利用从脑电图信号的SODP形状提取的几何特征及AsyLnCPSO-GA进行癫痫发作检测
Entropy (Basel). 2022 Oct 26;24(11):1540. doi: 10.3390/e24111540.
6
Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.该综合征的特征是静息态脑电图以抑制为主导的动力学。
Front Physiol. 2021 Dec 23;12:775172. doi: 10.3389/fphys.2021.775172. eCollection 2021.
7
MEG Node Degree Differences in Patients with Focal Epilepsy vs. Controls-Influence of Experimental Conditions.局灶性癫痫患者与对照组的脑磁图节点度差异——实验条件的影响
Brain Sci. 2021 Nov 30;11(12):1590. doi: 10.3390/brainsci11121590.
8
Case Report: Aperiodic Fluctuations of Neural Activity in the Ictal MEG of a Child With Drug-Resistant Fronto-Temporal Epilepsy.病例报告：一名耐药性额颞叶癫痫患儿发作期脑磁图中神经活动的非周期性波动
Front Hum Neurosci. 2021 Mar 4;15:646426. doi: 10.3389/fnhum.2021.646426. eCollection 2021.
9
Deep Brain Stimulation Increases Seizure Threshold by Altering REM Sleep and Delta Powers During NREM Sleep.深部脑刺激通过改变快速眼动睡眠和非快速眼动睡眠期间的δ波功率来提高癫痫阈值。
Front Neurol. 2020 Aug 12;11:752. doi: 10.3389/fneur.2020.00752. eCollection 2020.
10
Localization of the Epileptogenic Zone Using Interictal MEG and Machine Learning in a Large Cohort of Drug-Resistant Epilepsy Patients.在一大群耐药性癫痫患者中，利用发作间期脑磁图和机器学习定位癫痫发作起始区
Front Neurol. 2018 Aug 7;9:647. doi: 10.3389/fneur.2018.00647. eCollection 2018.
颞叶癫痫手术后早期和晚期发作复发的时间。
Epilepsia. 2013 Nov;54(11):1933-41. doi: 10.1111/epi.12389.
4
A neocortical delta rhythm facilitates reciprocal interlaminar interactions via nested theta rhythms.新皮层的三角波节律通过嵌套的θ节律促进层间的相互作用。
J Neurosci. 2013 Jun 26;33(26):10750-61. doi: 10.1523/JNEUROSCI.0735-13.2013.
5
Long-term outcomes after nonlesional extratemporal lobe epilepsy surgery.非致痫性颞叶外癫痫手术后的长期结果。
JAMA Neurol. 2013 Aug;70(8):1003-8. doi: 10.1001/jamaneurol.2013.209.
6
Correlation between magnetoencephalography-based "clusterectomy" and postoperative seizure freedom.基于脑磁图的“簇状切除术”与术后无癫痫发作的相关性。
Neurosurg Focus. 2013 Jun;34(6):E9. doi: 10.3171/2013.4.FOCUS1357.
7
Improved outcomes with earlier surgery for intractable frontal lobe epilepsy.早期手术治疗顽固性额叶癫痫可改善预后。
Ann Neurol. 2013 May;73(5):646-54. doi: 10.1002/ana.23862. Epub 2013 Mar 11.
8
Temporal lobe epilepsy surgery failures: a review.颞叶癫痫手术失败：综述
Epilepsy Res Treat. 2012;2012:201651. doi: 10.1155/2012/201651. Epub 2012 Apr 22.
9
Rates and predictors of long-term seizure freedom after frontal lobe epilepsy surgery: a systematic review and meta-analysis.额叶癫痫手术后长期无癫痫发作的比率和预测因素：系统评价和荟萃分析。
J Neurosurg. 2012 May;116(5):1042-8. doi: 10.3171/2012.1.JNS111620. Epub 2012 Feb 3.
10
The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study.成人癫痫手术的长期结果、缓解模式和复发：一项队列研究。
Lancet. 2011 Oct 15;378(9800):1388-95. doi: 10.1016/S0140-6736(11)60890-8.