Potin V V, Svechnikova F A, Soboleva E L
Akush Ginekol (Mosk). 1989 Jul(7):16-9.
The impact of methergoline, a serotonin antagonist, on the levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), prolactin, estradiol and progesterone was studied in the blood serum of 20 females with hyperprolactinemia-induced ovarian insufficiency who were under a ten-day course of its administration in a dose of 4-12 mg/day. Two patients were studied for gonadotrophin impulse secretion before and during methergoline treatment. It was revealed that the administration of the preparation led to a significant elevation of serum FSH and LH, estradiol and progesterone levels (up to the values characteristic of the preovulation phase) and enhancement of LH impulse secretion by the pituitary body. The possibility of dominant follicle growth and development was stated in the presence of persistent hyperprolactinemia. The authors supposed that the agent's effect was gained due to an enhanced secretion of the gonadotrophin-releasing hormone by the hypothalamus.
研究了血清素拮抗剂麦角新碱对20名高催乳素血症所致卵巢功能不全女性血清中促卵泡激素（FSH）、促黄体生成素（LH）、催乳素、雌二醇和孕酮水平的影响。这些女性接受了为期10天、剂量为4 - 12毫克/天的麦角新碱治疗。对两名患者在麦角新碱治疗前后进行了促性腺激素脉冲分泌研究。结果显示，该制剂的给药导致血清FSH、LH、雌二醇和孕酮水平显著升高（达到排卵前期的特征值），并增强了垂体的LH脉冲分泌。在持续性高催乳素血症的情况下，存在优势卵泡生长发育的可能性。作者推测，该药物的作用是由于下丘脑促性腺激素释放激素分泌增加所致。
