Nordvall S L, Berg T, Johansson S G, Lanner A
Int Arch Allergy Appl Immunol. 1982;67(2):132-8. doi: 10.1159/000233003.
Perennial desensitization therapy was given during a period of 3.5 years to 40 children allergic to grass pollen allergens. 20 patients were treated with a crude and another 20 with a purified timothy pollen extract. 8 children served as untreated controls. The concentration of total and specific IgE in the treated groups covaried with those in the control group. Neither a suppression of the seasonal booster effect nor a suppression of IgE synthesis attributable to the treatment was found. The rise of timothy-specific "blocking' IgG antibodies was more pronounced in the group treated with the purified extract than in the group treated with the crude extract. A significant difference was found only after 3.5 years of treatment. The amplitude of rise of IgG antibodies correlated significantly with the effect of the treatment as judged by repeated conjunctival titration test. The results suggest that a good IgG response is an indication of successful therapy and that a better IgG response may be achieved with purified allergen extracts.
对40名对草花粉过敏原过敏的儿童进行了为期3.5年的常年脱敏治疗。20名患者接受粗制提摩西花粉提取物治疗，另外20名接受纯化提摩西花粉提取物治疗。8名儿童作为未治疗的对照组。治疗组中总IgE和特异性IgE的浓度与对照组的浓度相关。未发现治疗对季节性增强效应的抑制作用，也未发现治疗对IgE合成的抑制作用。纯化提取物治疗组中提摩西特异性“阻断”IgG抗体的升高比粗制提取物治疗组更明显。仅在治疗3.5年后发现显著差异。IgG抗体升高的幅度与反复结膜滴定试验判断的治疗效果显著相关。结果表明，良好的IgG反应是治疗成功的指标，使用纯化过敏原提取物可能会获得更好的IgG反应。
