丙泊酚与硫喷妥钠作为产科麻醉诱导剂的比较。

A comparison between propofol and thiopentone as induction agents in obstetric anaesthesia.

作者信息

Moore J, Bill K M, Flynn R J, McKeating K T, Howard P J

机构信息

Department of Anaesthetics, Queen's University of Belfast.

出版信息

Anaesthesia. 1989 Sep;44(9):753-7. doi: 10.1111/j.1365-2044.1989.tb09263.x.

DOI:10.1111/j.1365-2044.1989.tb09263.x

PMID:2802123

Abstract

Two comparable series of 21 patients who had elective Caesarean section had general anaesthesia induced by thiopentone sodium 4.53 (SD 0.65) mg/kg or propofol 2.15 (SD 0.26) mg/kg. Maintenance was similar for both groups. Blood pressure was lower in the propofol group during the induction-delivery interval. Umbilical/maternal vein ratios for thiopentone and propofol were 8.5 and 7.2 respectively. Infant wellbeing as judged by Apgar score and cord blood analysis showed little difference between the two induction agents. Factors associated with uterine relaxation and bleeding were similar in the two groups.

摘要

两组各21例择期剖宫产患者分别接受硫喷妥钠4.53（标准差0.65）mg/kg或丙泊酚2.15（标准差0.26）mg/kg诱导全身麻醉。两组的维持麻醉方式相似。在诱导至分娩期间，丙泊酚组的血压较低。硫喷妥钠组和丙泊酚组的脐血/母血药物浓度比值分别为8.5和7.2。根据阿氏评分和脐血分析判断，两种诱导药物对婴儿健康的影响差异不大。两组中与子宫松弛和出血相关的因素相似。