Gregory M A, Gin T, Yau G, Leung R K, Chan K, Oh T E
Department of Anaesthesia and Intensive Care and Prince of Wales Hospital, Shatin, Hong Kong.
Can J Anaesth. 1990 Jul;37(5):514-20. doi: 10.1007/BF03006318.
Two propofol infusion regimens and a standard general anaesthetic were compared in thirty Chinese women undergoing elective Caesarean section. After induction of anaesthesia with propofol 2 mg.kg-1, ten patients received propofol 6 mg.kg-1.hr-1 and nitrous oxide 50 per cent in oxygen while ten were given propofol 9 mg.kg-1.hr-1 with 100 per cent oxygen. The other ten patients received thiopentone 4 mg.kg-1 and nitrous oxide 50 per cent in oxygen with enflurane one per cent. Maternal recovery times and psychomotor performance were recorded. Neonates were assessed by Apgar scores, neurologic and adapative capacity scores (NACS) and umbilical cord blood gas analysis. Haemodynamic changes were similar immediately following induction but the low propofol infusion group had the best haemodynamic stability subsequently. Recovery times were fastest in the low-infusion group but there were no differences in later postbox testing. Neonatal Apgar scores and umbilical blood gas analysis were similar but NACS at two hours were poorer in the high infusion group. A propofol infusion coupled with nitrous oxide appears to be a satisfactory technique for Caesarean section.
对30例行择期剖宫产的中国女性，比较了两种丙泊酚输注方案和一种标准全身麻醉方法。以2mg.kg-1丙泊酚诱导麻醉后，10例患者接受6mg.kg-1.hr-1丙泊酚和50%氧化亚氮混合氧气，另10例接受9mg.kg-1.hr-1丙泊酚和纯氧。其余10例患者接受4mg.kg-1硫喷妥钠、50%氧化亚氮混合氧气及1%恩氟烷。记录产妇恢复时间和精神运动表现。通过阿氏评分、神经和适应能力评分（NACS）及脐血血气分析对新生儿进行评估。诱导后即刻血流动力学变化相似，但随后低丙泊酚输注组血流动力学稳定性最佳。低输注组恢复时间最快，但后期的产后测试无差异。新生儿阿氏评分和脐血血气分析相似，但高输注组2小时时的NACS较差。丙泊酚输注联合氧化亚氮似乎是一种令人满意的剖宫产麻醉技术。
