Stern R C, Weiss C I, Steinbach J H, Evers A S
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110.
Anesth Analg. 1989 Nov;69(5):657-62.
Although isoflurane is frequently used during hypothermic cardiopulmonary bypass (CPB), its pharmacokinetics in these circumstances have not been described for systems employing membrane oxygenators. The current study details isoflurane uptake and elimination in an ex vivo model of hypothermic CPB, which uses a Scimed membrane oxygenator. Isoflurane uptake and elimination by blood are markedly delayed by the membrane oxygenator in this system. This is because the oxygenator membrane absorbs large amounts of anesthetic; the Scimed oxygenator membrane has a capacity for anesthetic equivalent to approximately 17 L of blood. As isoflurane absorption by the oxygenator may also delay anesthetic uptake and elimination in patients during CPB, further studies in human subjects are needed to define the clinical significance of anesthetic absorption by the membrane oxygenator.
尽管异氟烷在低温体外循环（CPB）期间经常使用，但在使用膜式氧合器的系统中，尚未对其在这些情况下的药代动力学进行描述。当前研究详细介绍了在使用Scimed膜式氧合器的低温CPB体外模型中异氟烷的摄取和消除情况。在该系统中，膜式氧合器显著延迟了血液对异氟烷的摄取和消除。这是因为氧合器膜吸收了大量麻醉剂；Scimed氧合器膜对麻醉剂的容纳能力相当于约17升血液。由于CPB期间氧合器对异氟烷的吸收也可能延迟患者体内麻醉剂的摄取和消除，因此需要在人体受试者中进行进一步研究，以确定膜式氧合器对麻醉剂吸收的临床意义。
