Ender L A, Lobakov A I, Vatazin A V, Filizhanko V N, Karpova E G
Anesteziol Reanimatol. 1989 May-Jun(3):25-8.
An experience of using discrete exchange plasmapheresis (DEP), filtration exchange plasmapheresis (FEP), hemofiltration (HF) and plasmafiltration (PF) in combination with ultraviolet (UV) irradiation of autoblood has been reviewed in 92 patients with pyogenic peritonitis. It has been shown that HF (PF) is an effective and pathogenetically grounded method of detoxication in patients with disseminated pyogenic peritonitis at a stage of polyorgan failure. FEP must be a method of choice during complex therapy at terminal phases of disseminated pyogenic peritonitis. The mechanisms of FEP therapeutic effect are based on elimination of a wide range of toxic substances, correction of severe metabolic disturbances, improvement of central and liver hemodynamics and, in combination with UV irradiation of autoblood, on bacteriocide and antihypoxic effect. The use of DEP is restricted to local pyogenic processes in the abdominal cavity.
回顾了92例化脓性腹膜炎患者使用间断性置换血浆术（DEP）、滤过置换血浆术（FEP）、血液滤过（HF）和血浆滤过（PF）并结合自体血紫外线（UV）照射的经验。结果表明，在多器官功能衰竭阶段的播散性化脓性腹膜炎患者中，HF（PF）是一种有效且基于发病机制的解毒方法。在播散性化脓性腹膜炎终末期的综合治疗中，FEP必须是首选方法。FEP治疗作用的机制基于消除多种有毒物质、纠正严重的代谢紊乱、改善中枢和肝脏血流动力学，以及与自体血紫外线照射相结合的杀菌和抗缺氧作用。DEP的应用仅限于腹腔局部化脓性病变。
