Saryan J A, Garrett P E, Kurtz S R
Department of Allergy and Dermatology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
Ann Allergy. 1989 Oct;63(4):322-4.
Two patients with extreme elevations in serum IgE were found to have falsely low levels of IgE when measured by a commercial immunoradiometric assay. Dilution studies performed on serum from both patients revealed the rise and subsequent fall of the dose-response curve characteristic of the high-dose "hook" or prozone effect. Specimens with unexpectedly low levels of serum IgE obtained by either commercial immunoradiometric assay or enzyme immunoassay should be reanalyzed after dilution.
两名血清IgE水平极高的患者在采用商业免疫放射分析测定时，发现IgE水平假性降低。对两名患者的血清进行的稀释研究显示，剂量反应曲线出现了高剂量“钩状”或前带效应特有的先上升后下降的情况。通过商业免疫放射分析或酶免疫分析获得的血清IgE水平意外降低的标本，应在稀释后重新分析。
