[早产母亲乳汁中巨噬细胞的免疫学方面]

[Immunologic aspects of the macrophages in the milk of preterm mothers].

作者信息

Rodríguez Rodríguez M C, Subiza Garrido-Lestache J L, Mateos Burguillo P, Casado de Frias E, Moro Serrano M, Gómez de la Concha E

机构信息

Servicio de Pediatría, Hospital Universitario San Carlos, Madrid.

出版信息

An Esp Pediatr. 1989 Jul;31(1):36-8.

PMID:2802405

Abstract

Number and function of milk macrophages from 25 healthy mothers delivering preterm (PHMMo) (mean gestational age 33 weeks) were compared with those obtained from 74 mothers with term delivery (THMMo). The average concentration of MMø in colostrum did not differ among both sources: 0.55 x 10(6)/ml (PHMMo) and 0.42 x 10(6)/ml (THMMo). The mean phagocytic index of PHMMo (3.35 yeasts/cell) and THMMo (3.40 yeasts/cell) was similar (p greater than 0.05); both cell types were significantly higher than control monocytes (CMo) (1.95 yeasts/cell) (p less than 0.001). The mean chemotactic function of PHMMo (11.58 cells/field) was significantly greater than THMMo (2.75 cells/field) (p less than 0.001). However, both milk cells showed lower chemotaxis than CMo (32.63 cells/field) (p less than 0.001).

摘要

将25名早产健康母亲（PHMMo）（平均孕周33周）的乳汁巨噬细胞数量和功能与74名足月分娩母亲（THMMo）的乳汁巨噬细胞进行了比较。初乳中MMø的平均浓度在两种来源之间没有差异：0.55×10⁶/ml（PHMMo）和0.42×10⁶/ml（THMMo）。PHMMo（3.35个酵母/细胞）和THMMo（3.40个酵母/细胞）的平均吞噬指数相似（p＞0.05）；两种细胞类型均显著高于对照单核细胞（CMo）（1.95个酵母/细胞）（p＜0.001）。PHMMo的平均趋化功能（11.58个细胞/视野）显著大于THMMo（2.75个细胞/视野）（p＜0.001）。然而，两种乳汁细胞的趋化性均低于CMo（32.63个细胞/视野）（p＜0.001）。