糖敏树枝状聚合物薄膜作为制备独立多层薄膜的牺牲层。

Sugar-sensitive dendrimer films as a sacrificial layer for the preparation of freestanding multilayer films.

作者信息

Sato Fumiya, Anzai Jun-Ichi

机构信息

Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.

出版信息

Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:118-122. doi: 10.1016/j.msec.2016.11.061. Epub 2016 Nov 17.

DOI:10.1016/j.msec.2016.11.061

PMID:28024567

Abstract

Multilayer thin films composed of poly(vinyl alcohol) (PVA) and phenylboronic acid-bearing poly(amidoamine) dendrimer (PBA-PAMAM) were used as a sacrificial layer for constructing freestanding polyelectrolyte films consisting of poly(styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH). Freestanding (PSS/PAH) films were successfully released from substrate by exposing composite (PVA/PBA-PAMAM)/(PSS/PAH) films (n=5 and 10) to sorbitol solutions under mild conditions at pH7.0-9.0. The film release was accelerated in solutions of higher sorbitol concentrations at pH9.0 as well as in solutions with lower concentration of NaCl. The results were rationalized based on the scission of boronate ester bonds between PBA-PAMAM and PVA in the (PVA/PBA-PAMAM) layer due to a competitive binding of sorbitol to PBA-PAMAM.

摘要

由聚乙烯醇（PVA）和含苯硼酸的聚酰胺胺树枝状大分子（PBA-PAMAM）组成的多层薄膜被用作牺牲层，用于构建由聚苯乙烯磺酸盐（PSS）和聚烯丙胺盐酸盐（PAH）组成的独立聚电解质薄膜。通过在pH7.0 - 9.0的温和条件下将复合（PVA/PBA-PAMAM）/（PSS/PAH）薄膜（n = 5和10）暴露于山梨醇溶液中，成功地从基底上释放出独立的（PSS/PAH）薄膜。在pH9.0的较高山梨醇浓度溶液以及较低NaCl浓度的溶液中，薄膜释放加速。基于山梨醇与PBA-PAMAM的竞争性结合导致（PVA/PBA-PAMAM）层中PBA-PAMAM与PVA之间的硼酸酯键断裂，对结果进行了合理的解释。