Martim Gedalias C, Pfeifer Carmem S, Girotto Emerson M
Materials Chemistry and Sensors Laboratories, Department of Chemistry, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900 Maringá, Paraná, Brazil.
Biomaterials and Biomechanics, Oregon Health and Science University, 611 SW Campus Dr, Portland, OR 97239, USA.
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:192-201. doi: 10.1016/j.msec.2016.11.050. Epub 2016 Nov 15.
The aim of this study was to synthesize and characterize new multifunctional-urethane-methacrylate monomers to be used as the organic matrix in restorative dental composites, and evaluate the main physical-chemical properties of the resulting material. Bis-GMA (bisphenol-A-diglycidylmethacrylate) and GDMA (glycerol dimethacrylate) were modified by reacting the hydroxyl groups with isocyanate groups of urethane-methacrylate precursors to result in the new monomeric systems U-(bis-GMA)-Mod and U-(GDMA)-Mod, U=Urethane and Mod=Modified. The modifications were characterized by FTIR and H NMR. The final monomeric synthesized system was used to prepare dental resins and composites. The physical-chemical properties were evaluated and compared with those of bis-GMA composites with varying filler contents or unfilled resins. U-(bis-GMA)-Mod and U-(GDMA)-Mod can be used to prepare dental restorative composites, with some foreseeable advantages compared with bis-GMA composites. One significant advantage is that these composites have the potential to be less toxic, once they presented a reduction of 50% in leaching of unreacted monomers extracted by solvent.
本研究的目的是合成并表征新型多功能聚氨酯 - 甲基丙烯酸酯单体，用作牙科修复复合材料的有机基质，并评估所得材料的主要物理化学性质。通过使双酚A - 二缩水甘油甲基丙烯酸酯（Bis - GMA）和甘油二甲基丙烯酸酯（GDMA）的羟基与聚氨酯 - 甲基丙烯酸酯前体的异氰酸酯基团反应，对其进行改性，从而得到新的单体体系U - (Bis - GMA) - Mod和U - (GDMA) - Mod，其中U代表聚氨酯，Mod代表改性。通过傅里叶变换红外光谱（FTIR）和核磁共振氢谱（H NMR）对改性进行表征。将最终合成的单体体系用于制备牙科树脂和复合材料。对其物理化学性质进行评估，并与不同填料含量的Bis - GMA复合材料或未填充树脂进行比较。U - (Bis - GMA) - Mod和U - (GDMA) - Mod可用于制备牙科修复复合材料，与Bis - GMA复合材料相比具有一些可预见的优势。一个显著优势是，这些复合材料的毒性可能更低，因为它们经溶剂萃取的未反应单体的浸出量减少了50%。
