State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Department of Stomatology, 923th Hospital of the Joint Logistics Support Force of PLA, Nanning, China.
J Dent Res. 2024 May;103(5):536-545. doi: 10.1177/00220345241232312. Epub 2024 Mar 28.
Dimethacrylate-based chemistries feature extensively as resin monomers in dental resin-based materials due to their distinguished overall performance. However, challenges endure, encompassing inadequate mechanical attributes, volumetric shrinkage, and estrogenicity. Herein, we first synthesized a novel resin monomer, 9-armed starburst polyurethane acrylate (NPUA), via the grafting-onto approach. Compared to the primary commercial dental monomer 2,2-bis [p-(2'-hydroxy-3'-methacryloxypropoxy) phenyl] propane (Bis-GMA) (with a viscosity of 1,174 ± 3 Pa·s and volumetric shrinkage of 4.7% ± 0.1%), the NPUA monomer achieves the lower viscosity (158 ± 1 Pa·s), volumetric shrinkage (2.5% ± 0.1%), and cytotoxicity ( < 0.05). The NPUA-based resins exhibit the higher flexural strength, flexural modulus, hardness, and hydrophobicity and lower volumetric shrinkage, water absorption, and solubility compared to the Bis-GMA (70 wt%)/TEGDMA (30 wt%) resins. The NPUA-based composites exhibit significantly higher flexural strength, flexural modulus, and hardness and lower volumetric shrinkage (171.4 ± 3.0 MPa, 12.6 ± 0.5 GPa, 2.0 ± 0.2 GPa, and 3.4% ± 0.2%, respectively) compared to the Bis-GMA group (120.3 ± 4.7 MPa, 9.4 ± 0.7 GPa, 1.5 ± 0.1 GPa, and 4.7% ± 0.2%, respectively; < 0.05). This work presents a viable avenue for augmenting the physicochemical attributes of dental resins.
基于二甲基丙烯酸酯的化学物质由于其出色的整体性能，广泛用作牙科树脂基材料中的树脂单体。然而，仍存在一些挑战，包括机械性能不足、体积收缩和雌激素活性。在此，我们首先通过接枝方法合成了一种新型的树脂单体，9-臂星型聚氨酯丙烯酸酯（NPUA）。与主要的商业牙科单体 2,2-双[对-（2'-羟基-3'-甲氧基丙烯酰氧基）苯基]丙烷（Bis-GMA）（粘度为 1174±3Pa·s，体积收缩率为 4.7%±0.1%）相比，NPUA 单体的粘度（158±1Pa·s）、体积收缩率（2.5%±0.1%）和细胞毒性（<0.05）更低。与 Bis-GMA（70wt%）/TEGDMA（30wt%）树脂相比，基于 NPUA 的树脂具有更高的弯曲强度、弯曲模量、硬度和疏水性，以及更低的体积收缩率、吸水率和溶解度。基于 NPUA 的复合材料的弯曲强度、弯曲模量和硬度显著更高，体积收缩率更低（171.4±3.0MPa、12.6±0.5GPa、2.0±0.2GPa 和 3.4%±0.2%，分别），而 Bis-GMA 组（120.3±4.7MPa、9.4±0.7GPa、1.5±0.1GPa 和 4.7%±0.2%，分别；<0.05）。这项工作为提高牙科树脂的物理化学性能提供了可行的途径。
