溶胶-凝胶法制备的羟基磷灰石-二氧化钛复合材料及双层涂层的生物相容性
Biocompatibility of sol-gel hydroxyapatite-titania composite and bilayer coatings.
作者信息
Sidane D, Rammal H, Beljebbar A, Gangloff S C, Chicot D, Velard F, Khireddine H, Montagne A, Kerdjoudj H
机构信息
Laboratoire de Génie de l'Environnement (LGE), Faculté de Technologie, Université de Bejaia, 06000, Bejaia, Alegria.
Equipe d'Accueil 4691 Biomatériaux et Inflammation en Site Osseux, SFR-CAP Santé (FED 4231), Université de Reims Champagne Ardenne, 1 Avenue du Maréchal Juin, 51100 Reims, France.
出版信息
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:650-658. doi: 10.1016/j.msec.2016.11.129. Epub 2016 Dec 5.
Titania-Hydroxyapatite (TiO/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO/HAP composite and TiO/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO/HAP composite once incubated in physiological conditions for 7days whereas the TiO/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO/HAP bilayer whereas on TiO/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating. Finally, TiO/HAP composite with hardness up to 0.6GPa and elastic modulus up to 18GPa, showed an increased corrosion resistance of 316L SS. In conclusion, the user-friendly sol-gel processes led to bioactive TiO/HAP composite buildup suitable for biomedical applications.
提出用二氧化钛-羟基磷灰石（TiO/HAP）增强涂层来提高316L不锈钢（316L SS）的生物活性和耐腐蚀性。在此，研究了旋涂和浸涂溶胶-凝胶工艺以构建两种涂层：TiO/HAP复合材料涂层和TiO/HAP双层涂层。物理化学表征突出了TiO/HAP复合材料在生理条件下孵育7天后的生物活性响应，而TiO/HAP双层涂层表现出不稳定性和溶解性。生物学分析显示人类干细胞在TiO/HAP双层涂层上无法黏附，而在TiO/HAP复合材料涂层上存在多边形细胞，其良好的行为证明了该复合涂层具有良好的生物相容性。最后，硬度高达0.6GPa且弹性模量高达18GPa的TiO/HAP复合材料涂层使316L SS的耐腐蚀性有所提高。总之，这种操作简便的溶胶-凝胶工艺促成了适用于生物医学应用的具有生物活性的TiO/HAP复合涂层的形成。
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