Abbasi Mahnaz, Farzam Seyed Amir, Mamaghani Zahra, Yazdi Zohreh
Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Qazvin University of Medical Sciences, Qazvin, Iran.
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S73-S76. doi: 10.1016/j.dsx.2016.12.008. Epub 2016 Dec 15.
Prevention of osteoporosis and bone fracture and the relationship between metabolic syndrome and bone density are controversial issues.
The aim of this study was to evaluate the association between metabolic syndrome and its components with bone mineral density in post menopausal women referred for bone mineral density (BMD) test.
A total of 143 postmenopausal women with at least one year of menopause experience participated in this cross-sectional study. Demographic and anthropometric characteristics for all participants were collected. Also, biochemical parameters including fasting blood sugar, Cholesterol (HDL and LDL), triglyceride were measured. Association between the components of metabolic syndrome and bone densitometry were analyzed by statistical methods.
In this study, 72% of participants did not have metabolic syndrome. Among them, 43.4% and 28.7% had osteoporosis and normal density, respectively. Of remaining participants with metabolic syndrome, 12.6% and 15.4% had osteoporosis and normal density, respectively. Among the metabolic syndrome components, waist circumference, HDL cholesterol, and waist to hip ratio were significantly associated with bone mass (P<0.05). Osteoporotic women had lower waist circumference and waist to hip ratio and higher HDL than women without osteoporosis. On the other hand, women with metabolic syndrome did not have significant differences than women without metabolic syndrome in terms of lumbar and femoral neck density (P>0.05).
Results from this study showed that metabolic syndrome and its components did not induce bone mass loss. The discrepancies of the studies in this area call for more large scale studies in population so as to prevent women problems in this area.
骨质疏松症和骨折的预防以及代谢综合征与骨密度之间的关系是存在争议的问题。
本研究旨在评估因骨密度（BMD）检测而转诊的绝经后女性中代谢综合征及其各组分与骨矿物质密度之间的关联。
共有143名绝经后至少1年的女性参与了这项横断面研究。收集了所有参与者的人口统计学和人体测量学特征。此外，还测量了包括空腹血糖、胆固醇（高密度脂蛋白和低密度脂蛋白）、甘油三酯在内的生化参数。采用统计学方法分析代谢综合征各组分与骨密度测定之间的关联。
在本研究中，72%的参与者没有代谢综合征。其中，分别有43.4%和28.7%患有骨质疏松症和骨密度正常。其余患有代谢综合征的参与者中，分别有12.6%和15.4%患有骨质疏松症和骨密度正常。在代谢综合征各组分中，腰围、高密度脂蛋白胆固醇和腰臀比与骨量显著相关（P<0.05）。骨质疏松症女性的腰围和腰臀比低于非骨质疏松症女性，而高密度脂蛋白高于非骨质疏松症女性。另一方面，患有代谢综合征的女性与未患代谢综合征的女性在腰椎和股骨颈密度方面没有显著差异（P>0.05）。
本研究结果表明，代谢综合征及其组分不会导致骨量丢失。该领域研究结果的差异需要在人群中开展更多大规模研究，以预防该领域的女性问题。
