Surfaces and Particle Engineering Laboratory (SPEL), Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK(1).
DryProTech Lab., Chemical Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382355, India.
Int J Pharm. 2017 Feb 25;518(1-2):138-154. doi: 10.1016/j.ijpharm.2016.12.045. Epub 2016 Dec 23.
Understanding interparticle interactions in powder systems is crucial to pharmaceutical powder processing. Nevertheless, there remains a great challenge in identifying the key factors affecting interparticle interactions. Factors affecting interparticle interactions can be classified in three different broad categories: powder properties, environmental conditions, and powder processing methods and parameters. Although, each of these three categories listed is known to affect interparticle interactions, the challenge remains in developing a mechanistic understanding on how combination of these three categories affect interparticle interactions. This review focuses on the recent advances on understanding the effect of powder properties, particularly particle properties, its effect on interparticle interactions and ultimately on powder bulk behaviour. Furthermore, this review also highlights how particle properties are affected by the particle processing route and parameters. Recent advances in developing a particle processing route to prepare particles with desired properties allowing desired interparticle interaction to deliver favoured powder bulk behaviour are also discussed. Perspectives for the development of potential particle processing approaches to control interparticle interaction are presented.
了解粉末系统中的颗粒间相互作用对于药物粉末加工至关重要。然而，确定影响颗粒间相互作用的关键因素仍然具有很大的挑战性。影响颗粒间相互作用的因素可以分为三类：粉末特性、环境条件以及粉末处理方法和参数。尽管这三类因素都已知会影响颗粒间相互作用，但仍然存在如何从机制上理解这三类因素如何组合影响颗粒间相互作用的挑战。本文综述了理解粉末特性（特别是颗粒特性）对颗粒间相互作用及其对粉末整体行为影响的最新进展。此外，本文还强调了颗粒特性如何受到颗粒处理途径和参数的影响。本文还讨论了开发颗粒处理途径以制备具有所需性质的颗粒的最新进展，这些颗粒具有所需的颗粒间相互作用，从而实现所需的粉末整体行为。提出了控制颗粒间相互作用的潜在颗粒处理方法的发展前景。
