Qi Yunfeng, Wang Dadong, Wang Daying, Jin Taicheng, Yang Liping, Wu Hui, Li Yaoyao, Zhao Jing, Du Fengping, Song Mingxia, Wang Renjun
Department of Bioscience, School of Life Science, Jilin Normal University, Siping, China
Department of Computer Science and Technology, Computer College, Jilin Normal University, Siping, China.
Database (Oxford). 2016 Dec 26;2016. doi: 10.1093/database/baw159. Print 2016.
Epigenetic drugs are chemical compounds that target disordered post-translational modification of histone proteins and DNA through enzymes, and the recognition of these changes by adaptor proteins. Epigenetic drug-related experimental data such as gene expression probed by high-throughput sequencing, co-crystal structure probed by X-RAY diffraction and binding constants probed by bio-assay have become widely available. The mining and integration of multiple kinds of data can be beneficial to drug discovery and drug repurposing. HEMD and other epigenetic databases store comprehensively epigenetic data where users can acquire segmental information of epigenetic drugs. However, some data types such as high-throughput datasets are not provide by these databases and they do not support flexible queries for epigenetic drug-related experimental data. Therefore, in reference to HEMD and other epigenetic databases, we developed a relatively comprehensive database for human epigenetic drugs. The human epigenetic drug database (HEDD) focuses on the storage and integration of epigenetic drug datasets obtained from laboratory experiments and manually curated information. The latest release of HEDD incorporates five kinds of datasets: (i) drug, (ii) target, (iii) disease, (vi) high-throughput and (v) complex. In order to facilitate data extraction, flexible search options were built in HEDD, which allowed an unlimited condition query for specific kinds of datasets using drug names, diseases and experiment types.Database URL: http://hedds.org/.
表观遗传药物是一类化合物，它们通过酶作用于组蛋白和DNA的无序翻译后修饰，并通过衔接蛋白识别这些变化。与表观遗传药物相关的实验数据，如通过高通量测序探测的基因表达、通过X射线衍射探测的共晶体结构以及通过生物测定探测的结合常数，已广泛可得。多种数据的挖掘和整合有助于药物发现和药物重新利用。HEMD等表观遗传数据库全面存储表观遗传数据，用户可以获取表观遗传药物的片段信息。然而，这些数据库并未提供一些数据类型，如高通量数据集，并且它们不支持对表观遗传药物相关实验数据进行灵活查询。因此，参考HEMD和其他表观遗传数据库，我们开发了一个相对全面的人类表观遗传药物数据库。人类表观遗传药物数据库（HEDD）专注于存储和整合从实验室实验获得的表观遗传药物数据集以及人工整理的信息。HEDD的最新版本纳入了五种数据集：（i）药物，（ii）靶点，（iii）疾病，（iv）高通量和（v）复合物。为了便于数据提取，HEDD内置了灵活的搜索选项，允许使用药物名称、疾病和实验类型对特定类型的数据集进行无限制条件查询。数据库网址：http://hedds.org/
