在皮肤疱疹豚鼠模型中评估脂质体包裹的干扰素的局部递送。
Topical delivery of liposomally encapsulated interferon evaluated in a cutaneous herpes guinea pig model.
作者信息
Weiner N, Williams N, Birch G, Ramachandran C, Shipman C, Flynn G
机构信息
College of Pharmacy, University of Michigan, Ann Arbor 48109.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1217-21. doi: 10.1128/AAC.33.8.1217.
Abstract
The topical delivery of liposomally encapsulated interferon was evaluated in the cutaneous herpes simplex virus guinea pig model. Application of liposomally entrapped interferon caused a reduction of lesion scores, whereas application of interferon formulated as a solution or as an emulsion was ineffective. The method of liposomal preparation rather than the lipid composition of the bilayers appeared to be the most important factor for reducing lesion scores. Only liposomes prepared by the dehydration-rehydration method were effective. This finding implied that the dehydration and subsequent rehydration of the liposomes facilitate partitioning of the interferon into liposomal bilayers, where the drug is positioned for transfer into the lipid compartment of the stratum corneum. Liposomes do not appear to function as permeation enhancers but seem to provide the needed physicochemical environment for transfer of interferon into the skin.
摘要
在皮肤单纯疱疹病毒豚鼠模型中评估了脂质体包裹干扰素的局部给药情况。应用脂质体包裹的干扰素可使损伤评分降低，而应用溶液或乳剂形式的干扰素则无效。脂质体制备方法而非双层膜的脂质组成似乎是降低损伤评分的最重要因素。只有通过脱水再水化法制备的脂质体才有效。这一发现表明，脂质体的脱水及随后的再水化促进了干扰素在脂质体双层膜中的分配，药物在双层膜中定位以便转移至角质层的脂质区室。脂质体似乎并非起渗透促进剂的作用，而是为干扰素向皮肤的转移提供所需的物理化学环境。
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