维生素D信号传导对乳腺癌激素受体状态及HER2表达的影响
Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer.
作者信息
Zhang Xi, Harbeck Nadia, Jeschke Udo, Doisneau-Sixou Sophie
机构信息
Brustzentrum der Universität München, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt, Klinikum der Ludwig-Maximilians-Universität, Maistraße 11, 80337, Munich, Germany.
Faculté des Sciences Pharmaceutiques, Université Paul Sabatier Toulouse III, 31062, Toulouse Cedex 09, France.
出版信息
J Cancer Res Clin Oncol. 2017 Jul;143(7):1107-1122. doi: 10.1007/s00432-016-2325-y. Epub 2016 Dec 26.
PURPOSE
Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways.
METHOD
In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today.
CONCLUSION
We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.
目的
乳腺癌是一个重大的全球公共卫生问题。它是全球女性死亡的主要原因，且发病率逐年上升。近年来，文献中关于维生素D在癌症中的保护作用的信息越来越多。越来越多的临床前和临床研究表明，维生素D的最佳水平可降低乳腺癌发生风险并调节癌症相关通路。
方法
在本综述中，我们聚焦于维生素D在乳腺癌中的重要性，特别讨论维生素D信号传导对雌激素受体和人表皮生长因子受体2（HER2）的影响，这两者是当今乳腺癌的两个主要生物标志物。
结论
我们探讨了针对乳腺癌中维生素D信号传导的当前和未来靶向治疗方法的可能性。
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