Aguilar-Medina Maribel, Escamilla-Tilch Monica, Frías-Castro Luis Octavio, Romero-Quintana Geovanni, Estrada-García Iris, Estrada-Parra Sergio, Granados Julio, Arambula Meraz Eliakym, Sánchez-Schmitz Guzman, Khader Shabaana Abdul, Rangel-Moreno Javier, Ramos-Payán Rosalío
Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, Culiacán, Sinaloa, Mexico.
Division of Immunogenetics, National Institute of Medical Sciences and Nutrition, CDMX, Mexico.
Ann Hum Genet. 2017 Jan;81(1):35-40. doi: 10.1111/ahg.12183. Epub 2016 Dec 27.
Despite the use of multidrug therapy, leprosy remains endemic in some countries. The association of several human leucocyte antigen (HLA) alleles and gene polymorphisms with leprosy has been demonstrated in many populations, but the major immune contributors associated to the spectrum of leprosy have not been defined yet. In this study, genotyping of HLA-A, -B, -DR, and -DQ alleles was performed in leprosy patients (n = 113) and control subjects (n = 117) from the region with the highest incidence for the disease in México. The odds of developing leprosy and lepromatous subtype were 2.12- and 2.74-fold higher in carriers of HLA-A28, and 2.48- and 4.14-fold higher for leprosy and dimorphic subtype in carriers of DQB106. Interestingly, DQB107 was overrepresented in healthy individuals, compared to patients with leprosy (OR = 0.08) and the lepromatous subtype (OR = 0.06). These results suggest that HLA-A28 is a marker for predisposition to leprosy and the lepromatous subtype and DQB106 to leprosy and the dimorphic subtype, while DQB107 might be a resistance marker in this Mestizo population.
尽管采用了多药疗法，但麻风病在一些国家仍然流行。在许多人群中已证实几种人类白细胞抗原（HLA）等位基因和基因多态性与麻风病有关，但与麻风病谱系相关的主要免疫因素尚未明确。在本研究中，对来自墨西哥该病发病率最高地区的麻风病患者（n = 113）和对照受试者（n = 117）进行了HLA-A、-B、-DR和-DQ等位基因的基因分型。HLA-A28携带者患麻风病和瘤型麻风亚型的几率分别高出2.12倍和2.74倍，DQB106携带者患麻风病和二型麻风亚型的几率分别高出2.48倍和4.14倍。有趣的是，与麻风病患者（OR = 0.08）和瘤型麻风亚型患者（OR = 0.06）相比，DQB107在健康个体中所占比例过高。这些结果表明，HLA-A28是麻风病和瘤型麻风亚型易感性的标志物，DQB106是麻风病和二型麻风亚型易感性的标志物，而DQB107可能是该混血人群中的抗性标志物。
