Bagüés Ana, Martín-Fontelles M Isabel, Esteban-Hernández Jesús, Sánchez-Robles Eva M
Área de Farmacología y Nutrición, Unidad asociada I+D+i al Instituto de Química Médica, Grupo de excelencia investigadora URJC-Banco de Santander-Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Madrid, Spain.
Área de Medicina Preventiva y Salud Pública, Facultad de Ciencias de la Salud. Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
Muscle Nerve. 2017 Oct;56(4):804-813. doi: 10.1002/mus.25538. Epub 2017 Apr 25.
To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation).
Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days.
Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short-lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius.
Carrageenan injected into the masseter and gastrocnemius induces a short-lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56: 804-813, 2017.
为了更好地理解慢性肌肉疼痛的病理生理学，有多种动物模型可模拟不同的急性/慢性疼痛状况，如注射角叉菜胶。我们之前的研究表明，在急性疼痛中，不同神经支配的肌肉之间存在差异。在本研究中，我们描述了角叉菜胶对两块肌肉的影响：咬肌（三叉神经支配）和腓肠肌（脊髓神经支配）。
将角叉菜胶（3%、6%和9%）注射到大鼠的咬肌和腓肠肌中。在14天内测量机械、热和化学伤害性感受阈值。
角叉菜胶在两块肌肉中均未诱发机械性异常性疼痛或热超敏反应。相反，它诱发了一种短暂的机械性痛觉过敏，咬肌中的反应比腓肠肌中更强烈。
注射到咬肌和腓肠肌中的角叉菜胶会诱发短暂的痛觉过敏。这些结果可能表明口面部肌肉对这种类型的损伤更敏感，因此，三叉神经和脊髓神经支配之间存在差异。《肌肉与神经》56: 804 - 813, 2017年。
