Gnatenko D A, Kopantsev E P, Sverdlov E D
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Biomed Khim. 2016 Nov;62(6):622-629. doi: 10.18097/PBMC20166206622.
Fibroblast growth factors belong to a family of growth factors that are involved in various processes in organism and have a wide range of biological functions. Specifically for pancreas, FGFs are important during both organogenesis and carcinogenesis. One of the main characteristic of pancreatic cancer, is it close interaction between cancer and stromal cells via different factors, including FGF. Pathological changes in FGF/FGFR signaling pathway is a complex process. The remodeling effects and stimulation of tumor growth are mostly depend not only on types of receptors, but also from their isoforms. FGF/FGFR signaling pathway is a perspective specific marker for cancer progression, and a potential drug target, which can be used for treatment of pancreatic cancer.
成纤维细胞生长因子属于生长因子家族，参与生物体的各种过程，具有广泛的生物学功能。具体到胰腺，成纤维细胞生长因子在器官发生和致癌过程中都很重要。胰腺癌的主要特征之一是癌细胞与基质细胞通过包括成纤维细胞生长因子在内的不同因子进行密切相互作用。成纤维细胞生长因子/成纤维细胞生长因子受体信号通路的病理变化是一个复杂的过程。其对肿瘤生长的重塑作用和刺激作用不仅大多取决于受体类型，还取决于其亚型。成纤维细胞生长因子/成纤维细胞生长因子受体信号通路是癌症进展的一个有前景的特异性标志物，也是一个潜在的药物靶点，可用于治疗胰腺癌。
