Kornmann M, Beger H G, Korc M
Department of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, USA.
Pancreas. 1998 Aug;17(2):169-75. doi: 10.1097/00006676-199808000-00010.
The fibroblast growth factor (FGF) family is a group of homologous heparin-binding polypeptides that has been implicated in a variety of human neoplasms and presently includes 14 members. FGF signaling is mediated by a dual-receptor system, consisting of four high-affinity tyrosine kinase receptors, termed fibroblast growth factor receptors (FGFRs), and of low-affinity heparan sulfate proteoglycan receptors that enhance ligand presentation to the FGFRs. Several FGFs, including FGF-1, -2, -3, -4, -5, -6, and -7, and several FGFR variants, among them the 2 immunoglobulin-like form and the IIIc splice variant of FGFR-1 and the keratinocyte growth factor receptor, a splice variant of FGFR-2, are expressed in human pancreatic cancer cell lines and are overexpressed in human pancreatic cancers or in the pancreas of chronic pancreatitis and, therefore, may play important roles in the pathobiology of these pancreatic diseases. This review summarizes the current information on the involvement of the FGF family and their receptors in human pancreatic cancer and chronic pancreatitis.
成纤维细胞生长因子（FGF）家族是一组同源的肝素结合多肽，与多种人类肿瘤有关，目前包括14个成员。FGF信号由双受体系统介导，该系统由四种高亲和力酪氨酸激酶受体（称为成纤维细胞生长因子受体（FGFR））和低亲和力硫酸乙酰肝素蛋白聚糖受体组成，后者可增强配体向FGFR的呈递。几种FGF，包括FGF-1、-2、-3、-4、-5、-6和-7，以及几种FGFR变体，其中包括FGFR-1的2种免疫球蛋白样形式和IIIc剪接变体以及FGFR-2的剪接变体角质形成细胞生长因子受体，在人胰腺癌细胞系中表达，并在人胰腺癌或慢性胰腺炎的胰腺中过表达，因此可能在这些胰腺疾病的病理生物学中发挥重要作用。本综述总结了关于FGF家族及其受体在人胰腺癌和慢性胰腺炎中的作用的当前信息。
