生长因子对胰腺癌细胞发育基因表达的可变影响
Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells.
作者信息
Gnatenko D A, Kopantzev E P, Sverdlov E D
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
出版信息
Dokl Biochem Biophys. 2018 Jul;481(1):217-218. doi: 10.1134/S1607672918040105. Epub 2018 Aug 31.
Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the expression of master genes regulating pancreatic development (SOX9, HNF3b, GATA-4, GATA-6, and HES1). This, in turn, caused changes in the expression profile of important transcription factors, embryonic development regulators. It was also found that the master genes belonging to the same family may cause opposite effects (suppression or enhancement of expression of a particular transcriptional regulator) in the same cell line.
用表皮生长因子（EGF）、肝细胞生长因子（HGF）、成纤维细胞生长因子-1（FGF-1）、成纤维细胞生长因子-2（FGF-2）、成纤维细胞生长因子-7（FGF-7）和成纤维细胞生长因子-10（FGF-10）生长因子刺激BxPC-3、Panc-1和MIA PaCA-2胰腺癌细胞，导致调控胰腺发育的主控基因（SOX9、HNF3b、GATA-4、GATA-6和HES1）的表达发生变化。这进而引起重要转录因子（胚胎发育调节因子）表达谱的变化。还发现，属于同一家族的主控基因在同一细胞系中可能会产生相反的作用（抑制或增强特定转录调节因子的表达）。
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