Thomas Gwendolyn A, Cartmel Brenda, Harrigan Maura, Fiellin Martha, Capozza Scott, Zhou Yang, Ercolano Elizabeth, Gross Cary P, Hershman Dawn, Ligibel Jennifer, Schmitz Kathryn, Li Fang-Yong, Sanft Tara, Irwin Melinda L
Department of Exercise Science, Syracuse University, Syracuse, New York, USA.
Yale Cancer Center, Yale University, New Haven, Connecticut, USA.
Obesity (Silver Spring). 2017 Feb;25(2):346-351. doi: 10.1002/oby.21729. Epub 2016 Dec 27.
This study examined the effect of 12 months of aerobic and resistance exercise versus usual care on changes in body composition in postmenopausal breast cancer survivors taking aromatase inhibitors (AIs).
The Hormones and Physical Exercise study enrolled 121 breast cancer survivors and randomized them to either supervised twice-weekly resistance exercise training and 150 min/wk of aerobic exercise (N = 61) or a usual care (N = 60) group. Dual-energy X-ray absorptiometry scans were conducted at baseline, 6 months, and 12 months to assess changes in body mass index, percent body fat, lean body mass, and bone mineral density.
At 12 months, the exercise group relative to the usual care group had a significant increase in lean body mass (0.32 vs. -0.88 kg, P = 0.03), a decrease in percent body fat (-1.4% vs. 0.48%, P = 0.03), and a decrease in body mass index (-0.73 vs. 0.17 kg/m , P = 0.03). Change in bone mineral density was not significantly different between groups at 12 months (0.001 vs. -0.006 g/cm , P = 0.37).
A combined resistance and aerobic exercise intervention improved body composition in breast cancer survivors taking AIs. Exercise interventions may help to mitigate the negative side effects of AIs and improve health outcomes in breast cancer survivors.
本研究探讨了为期12个月的有氧运动和抗阻运动与常规护理相比，对服用芳香化酶抑制剂（AIs）的绝经后乳腺癌幸存者身体成分变化的影响。
“激素与体育锻炼”研究招募了121名乳腺癌幸存者，并将他们随机分为两组，一组接受每周两次的有监督的抗阻运动训练和每周150分钟的有氧运动（N = 61），另一组接受常规护理（N = 60）。在基线、6个月和12个月时进行双能X线吸收法扫描，以评估体重指数、体脂百分比、瘦体重和骨密度的变化。
在12个月时，与常规护理组相比，运动组的瘦体重显著增加（0.32 vs. -0.88 kg，P = 0.03），体脂百分比降低（-1.4% vs. 0.48%，P = 0.03），体重指数降低（-0.73 vs. 0.17 kg/m²，P = 0.03）。两组在12个月时骨密度的变化无显著差异（0.001 vs. -0.006 g/cm²，P = 0.37）。
抗阻运动和有氧运动相结合的干预措施改善了服用AIs的乳腺癌幸存者的身体成分。运动干预可能有助于减轻AIs的负面副作用，并改善乳腺癌幸存者的健康结局。
