Yokum Sonja, Stice Eric
Oregon Research Institute, Eugene, Oregon, USA.
Obesity (Silver Spring). 2017 Feb;25(2):401-407. doi: 10.1002/oby.21728. Epub 2016 Dec 27.
Individuals with obesity versus those within a healthy weight range show brain volume differences, but it is unclear whether these differences reflect initial vulnerability factors or are secondary to weight gain.
One hundred sixty-two adolescents (M age = 15.3 ± 1.1; 81 females) with healthy weight were scanned at baseline. Sixty subjects (M baseline age: 15.2 ± 1.1; M follow-up age: 17.7 ± 1.2; 34 females) completed a second scan at 2- or 3-year follow-up. Voxel-based morphometry assessed global and regional gray matter (GM) and white matter (WM) volumes. Body fat percentage was assessed yearly over follow-up.
Baseline global/regional GM/WM volume did not predict body fat gain over follow-up. Adolescents who gained body fat showed greater decreases in GM volume in the putamen compared with those who showed loss of body fat. Adolescents who gained body fat showed greater increases in WM volume in the anterior cingulate cortex compared with those who showed stability of or loss of body fat.
Body fat gain versus stability and loss produce GM and WM volume changes, rather than baseline volumetric differences predicting body fat gain.
肥胖个体与体重处于健康范围的个体相比，脑容量存在差异，但尚不清楚这些差异是反映初始易患因素还是继发于体重增加。
对162名体重正常的青少年（平均年龄 = 15.3 ± 1.1岁；81名女性）进行基线扫描。60名受试者（基线平均年龄：15.2 ± 1.1岁；随访平均年龄：17.7 ± 1.2岁；34名女性）在2年或3年随访时完成了第二次扫描。基于体素的形态测量法评估了全脑和局部灰质（GM）及白质（WM）体积。在随访期间每年评估体脂百分比。
基线时的全脑/局部GM/WM体积并不能预测随访期间的体脂增加。与体脂减少的青少年相比，体脂增加的青少年壳核灰质体积减少得更多。与体脂稳定或减少的青少年相比，体脂增加的青少年前扣带回皮质白质体积增加得更多。
体脂增加与稳定及减少相比会导致GM和WM体积变化，而非基线体积差异预测体脂增加。
