Schwartz Deborah H, Dickie Erin, Pangelinan Melissa M, Leonard Gabriel, Perron Michel, Pike G Bruce, Richer Louis, Veillette Suzanne, Pausova Zdenka, Paus Tomáš
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada; Department of Psychology, University of Toronto, Canada.
Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada.
Neuroimage. 2014 Dec;103:192-201. doi: 10.1016/j.neuroimage.2014.09.030. Epub 2014 Sep 26.
Obesity, a major risk factor for cardiometabolic disease, is associated with variations in a number of structural properties in the adult brain, as assessed with magnetic resonance imaging (MRI). In this study, we investigated the cross-sectional relationship between visceral fat (VF), total body fat (TBF) and three MRI parameters in the brains of typically developing adolescents: (i) T1-weighted (T1W) signal intensity; (ii) T1W signal contrast between white matter (WM) and gray matter (GM); and (iii) magnetization transfer ratio (MTR). In a community-based sample of 970 adolescents (12-18 years old, 466 males), VF was quantified using MRI, and total body fat was measured using a multifrequency bioimpedance. T1W images of the brain were used to determine signal intensity in lobar GM and WM, as well as WM:GM signal contrast. A magnetization transfer (MT) sequence of MT(ON) and MT(OFF) was used to obtain MTR in GM and WM. We found that both larger volumes of VF and more TBF were independently associated with higher signal intensity in WM and higher WM:GM signal contrast, as well as higher MTR in both GM and WM. These relationships were independent of a number of potential confounders, including age, sex, puberty stage, household income and height. Our results suggest that both visceral fat and fat deposited elsewhere in the body are associated independently with structural properties of the adolescent brain. We speculate that these relationships suggest the presence of adiposity-related variations in phospholipid composition of brain lipids.
肥胖是心脏代谢疾病的主要风险因素，与成年大脑中许多结构特性的变化有关，这是通过磁共振成像（MRI）评估得出的。在本研究中，我们调查了典型发育青少年大脑中内脏脂肪（VF）、全身脂肪（TBF）与三个MRI参数之间的横断面关系：（i）T1加权（T1W）信号强度；（ii）白质（WM）和灰质（GM）之间的T1W信号对比度；以及（iii）磁化传递率（MTR）。在一个基于社区的970名青少年样本（12 - 18岁，466名男性）中，使用MRI对VF进行量化，并使用多频生物阻抗测量全身脂肪。大脑的T1W图像用于确定叶GM和WM中的信号强度以及WM:GM信号对比度。使用MT（开启）和MT（关闭）的磁化传递（MT）序列来获取GM和WM中的MTR。我们发现，更大体积的VF和更多的TBF均独立地与WM中更高的信号强度、更高的WM:GM信号对比度以及GM和WM中更高的MTR相关。这些关系独立于许多潜在的混杂因素，包括年龄、性别、青春期阶段、家庭收入和身高。我们的结果表明，内脏脂肪和身体其他部位沉积的脂肪均独立地与青少年大脑的结构特性相关。我们推测，这些关系表明大脑脂质的磷脂组成中存在与肥胖相关的变化。
