Institute of Organic and Analytical Chemistry, ICOA UMR 7311 CNRS, Université d'Orléans , rue de Chartres, 45100 Orléans, France.
LCM, CNRS, Ecole polytechnique, Université Paris Saclay , 91128 Palaiseau Cedex, France.
J Org Chem. 2017 Jan 20;82(2):1254-1259. doi: 10.1021/acs.joc.6b02612. Epub 2017 Jan 11.
An original cobalt-catalyzed ynamide carbozincation leading mainly to diverse 3-aryl enamides with mild reaction conditions and good functional-group tolerance has been developed. This reaction displays an excellent regio- and total stereoselectivity and opens the way to appealing synthetic applications. Moreover, this approach allows the selective synthesis of biologically relevant 3,5-disubstituted oxazolone frameworks.
一种新型钴催化的炔酰胺碳锌化反应，在温和的反应条件下和很好的官能团容忍度下，主要得到各种 3-芳基烯酰胺。该反应表现出极好的区域和立体选择性，并为有吸引力的合成应用开辟了道路。此外，这种方法还可以选择性地合成具有生物相关性的 3,5-二取代恶唑酮骨架。
