Rapid synthesis of 3-amino-1-isochromene from -ynamidyl het(aryl) aldehyde derivatives.

A simple and original efficient synthesis of 3-amino-1-isochromene bearing a bromine atom at the C-1 position a 6-endo-cyclization approach from generated -ynamidyl het(aryl) aldehyde derivatives is achieved under mild reaction conditions and with good yields. Original -ynamidyl benzaldehyde compounds were also successfully obtained.