采用眼前节谱域光学相干断层扫描评估类风湿关节炎患者的角膜和泪膜参数。
Assessment of Corneal and Tear Film Parameters in Rheumatoid Arthritis Patients Using Anterior Segment Spectral Domain Optical Coherence Tomography.
机构信息
a Department of Ophthalmology , Cairo University , Cairo , Egypt.
b Department of Rheumatology and Rehabilitation , Cairo University , Cairo , Egypt.
出版信息
Ocul Immunol Inflamm. 2018;26(4):632-638. doi: 10.1080/09273948.2016.1261165. Epub 2016 Dec 27.
PURPOSE
To study the corneal changes in rheumatoid arthritis (RA) patients in vivo, using spectral domain anterior segment optical coherence tomography (AS-OCT).
METHODS
A case-control study was done on 43 RA patients and 40 controls. The disease activity score (DAS28-ESR) was calculated and all participants had lower tear meniscus, corneal thickness, and epithelial thickness evaluation using AS-OCT.
RESULTS
The lower tear meniscus height (LTMH) and the lower tear meniscus area (LTMA) were significantly lower in the RA patients than in controls (p < 0.001). RA patients also had a significantly thinner central corneal thickness (p = 0.02) and their epithelium was found to be thinner in the superotemporal peripheral sector.
CONCLUSIONS
The LTMH and LTMA are significantly reduced in RA patients, despite the absence of clinical diagnosis of dry eye. RA patients have thinner corneal thickness and epithelial thickness than controls, which did not correlate with either disease duration or activity.
目的
使用频域眼前节光学相干断层扫描（AS-OCT）活体研究类风湿关节炎（RA）患者的角膜变化。
方法
对 43 例 RA 患者和 40 例对照者进行病例对照研究。计算疾病活动评分（DAS28-ESR），并使用 AS-OCT 对所有参与者进行低泪新月高度（LTMH）、角膜厚度和上皮厚度评估。
结果
RA 患者的低泪新月高度（LTMH）和低泪新月面积（LTMA）明显低于对照组（p < 0.001）。RA 患者的中央角膜厚度也明显较薄（p = 0.02），并且在外上周边象限的上皮更薄。
结论
尽管没有临床干燥性眼病的诊断，但 RA 患者的 LTMH 和 LTMA 明显降低。RA 患者的角膜厚度和上皮厚度比对照组薄，与疾病持续时间或活动无关。
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