Notch靶基因的动态染色质调控
Dynamic chromatin regulation at Notch target genes.
作者信息
Giaimo Benedetto Daniele, Oswald Franz, Borggrefe Tilman
机构信息
a Institute of Biochemistry, Justus Liebig University , Giessen , Germany.
b Department of Internal Medicine I , Center for Internal Medicine, University Medical Center Ulm , Ulm , Germany.
出版信息
Transcription. 2017 Jan;8(1):61-66. doi: 10.1080/21541264.2016.1265702. Epub 2016 Dec 27.
RBPJ is the central transcription factor that controls the Notch-dependent transcriptional response by coordinating repressing histone H3K27 deacetylation and activating histone H3K4 methylation. Here, we discuss the molecular mechanisms how RBPJ interacts with opposing NCoR/HDAC-corepressing or KMT2D/UTX-coactivating complexes and how this is controlled by phosphorylation of chromatin modifiers.
RBPJ是核心转录因子，通过协调抑制组蛋白H3K27去乙酰化和激活组蛋白H3K4甲基化来控制Notch依赖性转录反应。在此，我们讨论RBPJ如何与相反的NCoR/HDAC共抑制复合物或KMT2D/UTX共激活复合物相互作用的分子机制，以及这如何受染色质修饰因子磷酸化的调控。
Zotero 插件