Stepanova Ye I, Kolpakov I Ye, Zyhalo V M, Boyarsky V G
State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Melnykova Street, Kyiv, 04050, Ukraine.
Probl Radiac Med Radiobiol. 2016 Dec;21:336-344.
to determine the effectiveness of NO L arginine donator for correcting endothelial dysfunction in chil dren residents of radioactively contaminated areas.
A group of children residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected to assess the effectiveness of correcting endothelial dysfunction by NO L arginine donator according to selective screening. Biochemical parameters for the content of stable NO metabolites, serum L arginine; instrumental parameters of endothelium dependent vascular reaction on occlusion test, the ventilation capacity of the lungs were determined. A course of NO BetarhinТ dona tor, which active substance is L arginine, was received by examined children.
A group of children residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected according to selective screening. The pro nounced positive therapeutic effect, good tolerability, absence of side effects were observed in children with endothelial dysfunction, who were received a course of NO L arginine donator. It has been established that L argi nine use contributed to increasing the content of serum arginine, nitrite, nitrate, and amounts of NO metabolites in children with endothelial dysfunction. Bronchospasm elimination was noted after L arginine use in the significant part of examined patients. An increase in the diameter of the brachial artery and its space in the test with post occlusion reactive hyperemia after the use of L arginine course was revealed by an evaluation of indicators for endothelium dependent vasodilatation of the large vessels using ultrasound method visualizing the brachial artery lumen. This indicates an increase in endothelial vasomotor capacity.
确定一氧化氮-精氨酸供体对纠正受放射性污染地区儿童内皮功能障碍的有效性。
根据选择性筛查，选取一组有内皮功能障碍临床和副临床体征的受放射性污染地区儿童，以评估一氧化氮-精氨酸供体纠正内皮功能障碍的有效性。测定了稳定的一氧化氮代谢产物含量、血清精氨酸的生化参数；闭塞试验中内皮依赖性血管反应的仪器参数、肺通气能力。受试儿童接受了一个疗程的活性物质为精氨酸的一氧化氮-贝塔林供体。
根据选择性筛查，选取了一组有内皮功能障碍临床和副临床体征的受放射性污染地区儿童。接受一氧化氮-精氨酸供体疗程的内皮功能障碍儿童观察到明显的积极治疗效果、良好的耐受性且无副作用。已证实，使用精氨酸有助于增加内皮功能障碍儿童血清精氨酸、亚硝酸盐、硝酸盐的含量以及一氧化氮代谢产物的量。在大部分受试患者中，使用精氨酸后观察到支气管痉挛消除。通过超声方法可视化肱动脉管腔，评估大血管内皮依赖性血管舒张指标，发现使用精氨酸疗程后，闭塞后反应性充血试验中肱动脉直径及其间距增加。这表明内皮血管运动能力增强。
